Korean J Anesthesiol.  2005 Sep;49(3):385-394. 10.4097/kjae.2005.49.3.385.

The Comparison of Regional Cerebral Glucose Metabolism Using Positron Emission Tomography during Sevoflurane and Propofol Anesthesia in Human

• Jeong YB
• Choi IC
• Ju JY
• Kim JS
• Kim SD

• KMID: 2299141
• DOI: http://doi.org/10.4097/kjae.2005.49.3.385

Abstract

BACKGROUND: Recent increases in use of sevoflurane have made active researches on its effects in the cerebral metabolism. However, no specific data on brain glucose metabolism has been reported from human study. We compared the brain glucose metabolism during sevoflurane anesthesia with that of propofol anesthesia using positron emission tomography (PET) in the same human volunteers.
METHODS
PET scan was performed two times at intervals of one week in each eight volunteers. One scan was performed in sevoflurane anesthesia, and the other was performed in propofol anesthesia. Each was titrated to the point of unconsciousness. The scan was obtained by the 18fluorodeoxyglucose technique. Relative cerebral glucose metabolic rate (rCMRg) was assessed with statistical parametric mapping.
RESULTS
The regions of decreased rCMRg during sevoflurane aneshesia were the visual cortex, posterior parietal association area, primary somatosensory area, and premotor area. During propofol anesthesia the decreased regions were the visual inferotemporal area and prefrontal association area in addition to those area of sevoflurane anesthesia. The increased regions were the partial prefrontal association area, basal ganglia, cingulate, olfactory-limbic cortex, midbrain, and pons during sevoflurane anesthesia, and the primary motor area, insula, thalamus, medulla along with those area of sevoflurane during propofol anesthesia.
CONCLUSION
Propofol suppressed the rCMRg of neocortex area more than sevoflurane, and sevoflurane suppressed the rCMRg of paleocortex, telencephalon more than propofol when the unconsciousness level was achieved by anesthesia. Sevoflurane produces different effects on relative brain glucose metabolism with propofol.

Keyword

positron emission tomography; propofol; sevoflurane

MeSH Terms

Anesthesia*
Basal Ganglia
Brain
Electrons*
Glucose*
Healthy Volunteers
Humans*
Mesencephalon
Metabolism*
Neocortex
Pons
Positron-Emission Tomography*
Propofol*
Rabeprazole
Telencephalon
Thalamus
Unconsciousness
Visual Cortex
Volunteers
Glucose
Propofol