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Farnesylation-defective Rheb Increases Axonal Length Independently of mTORC1 Activity in Embryonic Primary Neurons

Choi S, Sadra A, Kang J, Ryu JR, Kim JH, Sun W, Huh SO

Rheb (Ras homolog enriched in the brain) is a small GTPase protein that plays an important role in cell signaling for development of the neocortex through modulation of mTORC1 (mammalian-target-of-rapamycin-complex-1)...
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Immunoreactivity of PCNA in the Cerebellum of Developing Guinea Pig

Kim DJ, Jun Y

The investigation of the embryonic development of the cerebellum has a long history. The postnatal normal development of the cerebellum in rodents and other animals became a popular topic for...
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Unified principles of thalamo-cortical processing: the neural switch

Ribary U, Doesburg S, Ward LM

It has been reported that cross-frequency interactions may play an important role in local processing within thalamus and neocortex, as well as information transfer between subcortical and cortico-cortical brain regions....
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Dementia due to Meningovascular Syphilis in Medial Temporal Lobe and Cognitive Rehabilitation

Ahn S, Jung KI, Yoo WK, Kang GY, Ohn SH

The temporal lobe is essential in saving declarative memory and plays an important role along with the cerebral neocortex in creating and maintaining long-term memory. Damage to the temporal lobe...
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Clinical Utility of Interictal High-Frequency Oscillations Recorded with Subdural Macroelectrodes in Partial Epilepsy

Cho JR, Joo EY, Koo DL, Hong SC, Hong SB

BACKGROUND AND PURPOSE: There is growing interest in high-frequency oscillations (HFO) as electrophysiological biomarkers of the epileptic brain. We evaluated the clinical utility of interictal HFO events, especially their occurrence...
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Topographical Propagation of alpha-synuclein Pathology in Parkinson's Disease: Phenomenology and Hypothetical Mechanism

Hyun M, Lee SJ

Parkinson's disease is an age-related, slowly progressing neurodegenerative disorder characterized by abnormal deposition of aggregated alpha-synuclein in neuronal cell bodies (Lewy bodies) and neurites (Lewy neurites), as well as in...
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Identification of 1,531 cSNPs from Full-length Enriched cDNA Libraries of the Korean Native Pig Using in Silico Analysis

Oh Y, Nguyen DT, Park K, Dirisala V, Choi H, Park C

  • KMID: 2053226
  • Genomics Inform.
  • 2009 Jun;7(2):65-84.
Sequences from the clones of full-length enriched cDNA libraries serve as valuable resources for functional genomics related studies, genome annotation and SNP discovery. We analyzed 7,392 high-quality chromatograms (Phred value...
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Brain Mapping for Memory and Learning

Park KM, Kim JJ

  • KMID: 2287066
  • Korean J Psychopharmacol.
  • 2007 Jul;18(4):199-210.
Functional magnetic resonance imaging and positron emission tomography studies have identified brain regions associated with different forms of memory and learning. The purpose of this study was to summarize the...
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Effects of Quetiapine on the Immobilization Stress-induced BDNF and CRF Expression in Rat Brain

Park SW, Lee SK, Kim YK, Lee SJ, Joo MJ, Rhee CG, Kim YH

  • KMID: 2287364
  • Korean J Psychopharmacol.
  • 2006 May;17(3):291-301.
OBJECTIVE: In this study we examined the effects of quetiapine on the immobilization stress-induced brain-derived neurotrophic factor (BDNF) and corticotropin-releasing factor (CRF) expression in rat brain. We also assessed the...
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Pathogenic Mechanism of Alzheimer's Disease

Han SH

  • KMID: 2053696
  • Hanyang Med Rev.
  • 2006 Feb;26(1):4-13.
Alzheimer's disease (AD) is regarded as a prototype of the neurodegenerative disorder characterized by progressive memory impairment and multiple cognitive deficits in mid- to late- life. Its pathological hallmarks consist...
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Immunohistochemical Study on GTP-binding Rab6 Expression in the Hippocampal Cortices of the Alzheimer Brain

Cheon YH, Kang YJ, Lee JH, Pyo JS, Baik TK

  • KMID: 2092863
  • Korean J Anat.
  • 2005 Oct;38(5):451-459.
The ras-related GTP binding protein, rab6, is located in late Golgi compartment. Modulation of beta-and gamma-secretase activity may lead to production of beta-amyloid fragments that are ultimately deposited in senile...
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Dopamine Modulates Corticostriatal Synaptic Transmission through Both D1 and D2 Receptor Subtypes in Rat Brain

Lee HH, Choi SJ, Kim KJ, Cho HS, Kim SY, Sung KW

  • KMID: 1600108
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):263-268.
Striatum has important roles in motor control, habitual learning and memory. It receives glutamatergic inputs from neocortex and thalamus, and dopaminergic inputs from substantia nigra. We examined effects of dopamine...
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The Comparison of Regional Cerebral Glucose Metabolism Using Positron Emission Tomography during Sevoflurane and Propofol Anesthesia in Human

Jeong YB, Choi IC, Ju JY, Kim JS, Kim SD

BACKGROUND: Recent increases in use of sevoflurane have made active researches on its effects in the cerebral metabolism. However, no specific data on brain glucose metabolism has been reported from...
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A Case of ReVersible MRI and SPECT Abnormalities in the Neocortex of the Temporal and Parietal Lobes after a Generalized Seizure

Cho YW, Lee JB, Sohn SI, Lee H, Lim JG, Yi SD, Sohn CH, Won KS, Zeon SK

  • KMID: 2343151
  • J Korean Neurol Assoc.
  • 2005 Apr;23(2):268-270.
We report a case with reVersible temporal and parietal neocortical abnormalities detected by MRI and SPECT following a brief seizure. Post ictal MRI abnormalities may indicate an underlying structural abnormality,...
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Cortical Representation to Odorant Stimulation: Statistical Non-parametric Mapping of Low Resolution Electro magnetic Tomography (LORETA)

Jung KY, Kim JM, Lee IK, Kim JH, Joo EY, Hong SB, Byun HS, Lee JH

  • KMID: 2343081
  • J Korean Neurol Assoc.
  • 2004 Aug;22(4):334-339.
BACKGROUND: Although olfactory stimulation has been known to produce effects on human mood and cognition, the specific EEG patterns of activity was reported diversely. The purpose of this study was...
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The Effect of Resection Extent Upon Postoperative Outcome of Seizures and Memory in Anterior Temporal Lobectomy with Amygdalohippocampectomy

Joo EY, Lee EK, Tae WS, Kim JH, Han SJ, Jin JH, Seo DW, Hong SC, Lee MH, Byun HS, Kim MH, Kim S, Hong SB

  • KMID: 2137396
  • J Korean Epilepsy Soc.
  • 2004 Jun;8(1):54-60.
PURPOSE: To investigate the relationship of the resection extent of hippocampus and temporal neocortex with the postsurgical outcome in patients with mesial temporal lobe epilepsy (TLE). METHODS: Sixty-eight patients with...
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Expression of Major Gangliosides in Normal and Alzheimer Disease Brain

Lee MC, Woo YJ, Kim SU, Tai T

  • KMID: 1725940
  • Korean J Pathol.
  • 2002 Dec;36(6):400-405.
BACKGROUND: GM1 ganglioside-bound amyloid beta-protein (GM1/A) has been reported to be involved with senile plaque formation in Alzheimer disease. METHODS: To investigate the binding of major gangliosides on senile plaques and...
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Postnatal Development of Transforming-growth Factor-alpha and Epidermal Growth Factor Receptor-immunoreactive Neurons in the Cerebral Cortex of the Rat

Chung YY, Kim NH, Kim JJ, Moon JS, Park YL, Ryu SY, Kim HK

  • KMID: 1559310
  • Korean J Anat.
  • 2002 Aug;35(4):269-284.
Transforming growth factor-alpha (TGF-alpha ) and epidermal growth factor receptor (EGFR) immunoreactivities were examined in the cerebral cortex of the rat during postnatal development. TGF-alpha -immunoreactive cells were found at...
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Postnatal Development of Brain -Derived Neurotrophic Factor: Immunoreactive Neuron System of the Rat Brain

Kim JK, Park WH, Kim SY, Cho HJ

  • KMID: 2092792
  • Korean J Anat.
  • 2002 Jun;35(3):249-260.
BDNF is a protein that allows the survival and differentiation of the central nervous system. In the present study, we have examined the postnatal development of BDNF -immunoreactive (IR) neuron...
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Postnatal Development of Epidermal Growth Factor Receptor: Immunoreactivity in the Cerebral Cortex of the Rat

Chung YY, Kim JJ

  • KMID: 1559158
  • Korean J Anat.
  • 2002 Feb;35(1):43-52.
Epidermal growth factor receptor (EGFR), a 170-kDa transmembrane glycoprotein, appears to mediate epidermal growth factor (EGF) activity. Transforming growth factor-alpha and EGF produce their biological effects in numerous systems by...
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