Korean Diabetes J.  2008 Jun;32(3):236-242. 10.4093/kdj.2006.32.3.236.

Effects of Telmisartan Compared with Valsartan on Plasma Adiponectin Levels and Arterial Stiffness in Patients with Type 2 Diabetes: A Pilot Study

• Park SY
• Kim SG
• Park J
• Lee YJ
• Kim HY
• Seo JA
• Kim NH
• Choi KM
• Baik SH
• Choi DS

• KMID: 2298094
• DOI: http://doi.org/10.4093/kdj.2006.32.3.236

Abstract

BACKGROUND: Telmisartan, used for the treatment of hypertension, has been shown to function as a partial agonist of peroxime proliferative activated receptor-nu (PPAR-nu). Theoretically, telmisartan which simultaneously blocks the angiotensin II receptor and activates PPAR-nu should be more effective in improving atherosclerotic surrogate markers than angiotensin II receptor blockers alone. Therefore, this pilot study was designed to evaluate and compare the efficacy of telmisartan and valsartan on plasma adiponectin levels and pulse wave velocity as a marker of arterial stiffness in patients with type 2 diabetes.
METHODS
Thirty two patients with type 2 diabetes (mean duration 7.6 +/- 5.1 years) taking oral hypoglycemic agents were randomly assigned to receive telmisartan or valsartan for 12 weeks.
RESULTS
Telmisartan and valsartan treatment significantly increased circulating adiponectin levels (P = 0.013 and P = 0.013, respectively) and reduced systolic (P = 0.001 and P = 0.002, respectively) and diastolic blood pressure (P = 0.001 and P < 0.001, respectively), and brachial-ankle PWV (P = 0.019 and P = 0.002, respectively), without significant differences between the two treatments. Before and after treatment, the fasting plasma glucose, interleukin-6, homeostasis model of assessment insulin resistance (HOMAIR) levels and lipid profile were unchanged in both treatment groups.
CONCLUSION
Contrary to our expectation, telmisartan, even with its partial PPAR-nu activity, is not superior to valsartan in improving plasma adipocytokine levels and arterial stiffness in patients with type 2 diabetes. These data suggest that the partial PPAR-nu activity of telmisartan beyond valsartan may have less significant therapeutic implications than expected in treating patients with type 2 diabetes.

Keyword

Adiponectin; Pulse wave velocity; Telmisartan; Type 2 diabetes; Valsartan

MeSH Terms

Adiponectin
Angiotensin Receptor Antagonists
Benzimidazoles
Benzoates
Biomarkers
Blood Pressure
Fasting
Glucose
Homeostasis
Humans
Hypertension
Hypoglycemic Agents
Insulin Resistance
Interleukin-6
Pilot Projects
Plasma
Pulse Wave Analysis
Receptors, Angiotensin
Tetrazoles
Valine
Vascular Stiffness
Valsartan
Adiponectin
Angiotensin Receptor Antagonists
Benzimidazoles
Benzoates
Glucose
Hypoglycemic Agents
Interleukin-6
Receptors, Angiotensin
Tetrazoles
Valine

Figure

• 

  Fig. 1 Changes of serum adiponectin levels and baPWV from baseline to week 12 in the telmisaran and valsartan groups.

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