Korean Circ J.  1998 Sep;28(9):1590-1599. 10.4070/kcj.1998.28.9.1590.

The Role of Angiotensin Converting Enzyme inhibitor in Ventricular Remodeling after Experimental Nontransmural Myocardial Infarction- Effects on Transforming Growth Factor-beta 1 Expression

• Youn TJ
• Kim SY
• Kim HS
• Kim EJ
• Kim SY
• Chung EJ
• Seo JW
• Oh BH

• KMID: 2298008
• DOI: http://doi.org/10.4070/kcj.1998.28.9.1590

Abstract

BACKGROUND
With the application of early reperfusion by thrombolysis after acute MI, the importance of nontransmural infarction is increasing. We evaluated 1) the changes of LV dimension, LV fibrosis and transforming growth factor-beta1 (TGF-beta1) mRNA expression in a rat model of nontransmural infarction and 2) effects of angiotensin converting enzyme inhibitor (ACEI) and angiotensin II receptor blocker (ATRB) treatment after nontransmural infarction.
METHOD AND RESULTS
Female Sprague-Dawley rats were subjected to 45 minutes of coronary occlusion followed by reperfusion, and at 5 days after the operation, animals were randomized to untreated (MI-vehicle, n=19), captopril-treated (MI-captopril, n=15) and losartan-treated (MI-losartan, n=14) groups. LV dimension, measured by transthoracic echocardiography, was significantly increased at 26 days after MI, and both captopril and losartan treatment inhibited LV cavity dilatation (LV end-diastolic dimension (mm): MI-vehicle, MI-captopril, MI-losartan; 8.6 +/- 0.2, 7.8 +/- 0.2, 8.0 +/- 0.2, p<0.05 vs. MI-vehicle each). Interstitial fibrosis was reduced with both captopril and losartan treatment (p<0.05 vs. MI-vehicle). TGF-beta1 mRNA increased 2.6 fold at 10 days (p<0.05 vs. pre-MI), and normalized at 26 days after nontransmural MI. Captopril and losartan treatment blocked the induction of TGF-beta1 expression after nontransmural MI (p=S vs. pre-MI).
CONCLUSION
After large nontransmural MI, ACEI and ATRB treatments attenuate LV remodeling and decrease interstitial fibrosis, at least partly by blocking the acute induction of TGF-beta1 mRNA expression.

Keyword

Nontransmural myocardial infarction; Remodeling; Transforming growth factor; Captopril; Losartan

MeSH Terms

Angiotensins*
Animals
Captopril
Coronary Occlusion
Dilatation
Echocardiography
Female
Fibrosis
Humans
Infarction
Losartan
Models, Animal
Peptidyl-Dipeptidase A*
Rats, Sprague-Dawley
Receptors, Angiotensin
Reperfusion
RNA, Messenger
Transforming Growth Factor beta1
Transforming Growth Factors
Ventricular Remodeling*
Angiotensins
Captopril
Losartan
Peptidyl-Dipeptidase A
RNA, Messenger
Receptors, Angiotensin
Transforming Growth Factor beta1
Transforming Growth Factors