Chonnam Med J.
2006 Apr;42(1):16-22.
Clinical Effects of a Fixed Dose Combination Therapy with Angiotensin Converting Enzyme Inhibitor and Diuretics in Patients with Myocardial Infarction with Left Ventricular Failure
- Affiliations
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- 1The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medicine Sciences, Gwangju, Korea. myungho@chollian.net
Abstract
- Angiotensin converting enzyme inhibitor (ACEI) has been known to be effective in the prevention of left ventricular remodeling following myocardial infarction. However, little data is available about the clinical effects of combined ACEI with hydrochlorothiazide in ischemic heart failure after myocardial infarction. Thirty patients (60.3+/-10.8 years, M : F=26 : 4) with myocardial infarction who had low left ventricular ejection fraction (EF) after successful percutaneous coronary intervention (PCI) were included. A combined agent of ACEI and thiazide (Moexipril 15 mg + Hydrochlorothiazie 25 mg) was administrated for over 18 weeks. Clinical symptoms of dyspnea, laboratory findings, left ventricular dimension and function, and wall motion score index by echocardiogram were observed during 18-week. Functional class according to New York Heart Association improved from 2.27+/-0.79 to 0.41+/-0.56 at 18 weeks (p=0.03). Left ventricular ejection fraction increased from 44.6+/-5.8% to 53.3+/-8.6% (p=0.01). Wall motion score index improved from 1.60+/-0.30 to 1.37+/-0.29 (p=0.03). The level of brain natriuretic peptide (BNP) decreased from 1181.4+/-1230.4 pg/dL to 108.9+/-85.6 pg/dl at 18 weeks after therapy (p<0.001). A fixed dose of ACEI with diuretics is effective in the prevention of left ventricular remodeling in patients with myocardial infarction with left ventricular failure.
MeSH Terms
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Angiotensin-Converting Enzyme Inhibitors
Angiotensins*
Diuretics*
Dyspnea
Heart
Heart Failure
Humans
Hydrochlorothiazide
Myocardial Infarction*
Natriuretic Peptide, Brain
Peptidyl-Dipeptidase A*
Percutaneous Coronary Intervention
Stroke Volume
Ventricular Remodeling
Angiotensin-Converting Enzyme Inhibitors
Angiotensins
Diuretics
Hydrochlorothiazide
Natriuretic Peptide, Brain
Peptidyl-Dipeptidase A
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