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Changes of Bax, Bcl-2, CCR-2, MCP-1, and TGF-β1 genes in the left ventricle of spontaneously hypertensive rat after losartan treatment

Lee H, Kim KC, Hong YM

PURPOSE: Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by...
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Losartan Prevents Maladaptive Auditory-Somatosensory Plasticity After Hearing Loss via Transforming Growth Factor-β Signaling Suppression

Mun SK, Han KH, Baek JT, Ahn SW, Cho HS, Chang MY

OBJECTIVES: Hearing loss disrupts the balance of auditory-somatosensory inputs in the cochlear nucleus (CN) of the brainstem, which has been suggested to be a mechanism of tinnitus. This disruption results...
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Microarray Analysis in Spontaneously Hypertensive Rat Heart after Losartan Treatment

Lee SW, Kim Y, Kim KC, Sohn S, Hong YM

OBJECTIVES: Spontaneously hypertensive rats (SHR) are frequently used as rat models of essential hypertension. The mechanism for the development of hypertension is complicated and it is unknown. The renin-angiotensin system...
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Comparison of Inhibitory Effects between Enalapril and Losartan on Adrenal Catecholamine Secretion

Lim HJ, Koh YY, Lim DY

BACKGROUND: The present study was attempted to compare enalapril, an angiotensin-converting enzyme inhibitor with losartan an angiotensin II (Ang II) receptor blocker in the inhibitory effects on the secretion of...
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Simvastatin and Losartan Differentially and Synergistically Inhibit Atherosclerosis in Apolipoprotein E-/- Mice

Lee BS, Choi JY, Kim JY, Han SH, Park JE

BACKGROUND AND OBJECTIVES: Since statins and angiotensin receptor blockers are a frequently prescribed combination in patients with atherosclerotic cardiovascular diseases, we tested the interactive effects of simvastatin and losartan on...
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Differential brain angiotensin-II type I receptor expression in hypertensive rats

Braga VA

Blood-borne angiotensin-II (Ang-II) has profound effects in the brain. We tested the hypothesis that Ang-II-dependent hypertension involves differential Ang-II type I (AT1) receptors expression in the subfornical organ (SFO) and...
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Effects of Spironolactone and Losartan on Diabetic Nephropathy in a Type 2 Diabetic Rat Model

Lee MY, Shim MS, Kim BH, Hong SW, Choi R, Lee EY, Nam SM, Kim GW, Shin JY, Shin YG, Chung CH

BACKGROUND: While there is an evidence that the anti-inflammatory properties of spironolactone can attenuate proteinuria in type 2 diabetes, its effects on vascular endothelial growth factor (VEGF) expression in diabetic...
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Effects of Losartan Administration on Uric acid Transporters in Rat Kidney

Kim S, Lee CH, Kang CM, Kim GH

  • KMID: 2012309
  • J Korean Soc Hypertens.
  • 2010 Jun;16(2):19-27.
BACKGROUND: Losartan, an angiotensin II receptor blockade, has been reported to decrease the serum uric acid level through its uricosuric action. However, the mechanism by which losartan affects renal handling...
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Losartan Inhibits Vascular Smooth Muscle Cell Proliferation through Activation of AMP-Activated Protein Kinase

Kim JE, Choi HC

Losartan is a selective angiotensin II (Ang II) type 1 (AT1) receptor antagonist which inhibits vascular smooth muscle cells (VSMCs) contraction and proliferation. We hypothesized that losartan may prevent cell...
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Effects of Losartan on Catecholamine Release in the Isolated Rat Adrenal Gland

Noh HJ, Kang YS, Lim DY

The aim of this study was to determine whether losartan, an angiotensin II (Ang II) type 1 (AT1) receptor could influence the CA release from the isolated perfused model of...
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Losartan/Hydrochlorothiazide Fixed Combination Versus Amlodipine Monotherapy in Korean Patients With Mild to Moderate Hypertension

Chung JW, Lee HY, Kim CH, Seung IW, Shin YW, Jeong MH, Cho MC, Oh BH

BACKGROUND AND OBJECTIVES: The antihypertensive efficacy and tolerability of losartan (LST) in fixed combination with hydrochlorothiazide (HCTZ) has not been compared to those of amlodipine monotherapy in Asians. This is...
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Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan

Kang ES, Kim BS, Kim CH, Seo GH, Han SJ, Chun SW, Hur KY, Ahn CW, Ha H, Jung M, Cha BS, Lee HC

BACKGROUND: Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. We examined...
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Effect of Losartan Treatment on Proteinuria and Urinary Transforming Growth Factor-beta1 in Human Chronic Glomerulonephritis

Park HC, Kim BS, Choi HY, Kang SW, Choi KH, Ha SK, Lee HY, Han DS

  • KMID: 2254358
  • Korean J Nephrol.
  • 2004 Mar;23(2):231-240.
BACKGROUND: Urinary TGF-beta1 reflects intrarenal TGF-beta1 production and is increased in patients with progressive nephropathies. We studied the effects of angiotensin receptor blocker (ARB) on serum and urinary TGF-beta1 excretion...
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Comparison of ANG II-mediated [Ca2+i, IP3 Production and [ATP]i in Isolated Renal Proximal Convoluted Tubules of Adult SHR and WKY

Kwak JO, Kim HW, Cha SH

  • KMID: 2254877
  • Korean J Nephrol.
  • 2004 Nov;23(6):848-858.
BACKGROUND: The renin angiotensin syaimstem plays an important role in hypertension. Therefore, the purpose of this study was to investigate the comparison of responsiveness to angiotensin II (ANG II) in...
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Effect of Central Losartan on DOCA-Salt Hypertension Rats

Lee SJ, Park CG, Park JS, Kim EJ, Shin SH, Jin DG, Ahn JC, Seo HS, Oh DJ, Ro YM

BACKGROUND: The purpose of this study was to investigate whether brain AT1 receptor stimulation contributes as a hypertensive mechanism to deoxycorticosterone acetate (DOCA)-salt hypertension. METHODS: 1) Acute injection:Losartan (1 mg/4...
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Inhibitory Effect of Angiotensin II Receptor Antagonist on the Contraction and Growth of Hepatic Stellate Cells

Baik SK, Jo HS, Suk KT, Kim JM, Lee BJ, Choi YJ, Kim HS, Lee DK, Kwon SO, Lee KI, Cha SK, Park KS, Kong ID

  • KMID: 772535
  • Korean J Gastroenterol.
  • 2003 Aug;42(2):134-141.
BACKGROUNDS/AIMS: This study aimed to investigate the effects of angiotensin II (ANG II) and its receptor antagonist (losartan) on the contraction and growth of HSCs. METHODS: HSCs were isolated...
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Effects of Central GABA and Glutamate on Blood Pressure and Single Unit Spikes in the RVLM of Rats

Park JS, Lee ZI, Jang JH, Ahn DK

  • KMID: 2285244
  • Korean J Physiol Pharmacol.
  • 2002 Jun;6(3):149-154.
The blood pressure (BP) is regulated by the nervous system and humoral factors, such as renin- angiotensin system, vasopressin and others. In the present study, we examined the central effects...
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Changes in Laminin beta 1 Chain Expression in Renal Cortex by the Intervention with Cilazapril and Losartan on Adriamycin-Induced Nephropathy

Kim TJ, Chung HS, Paik DJ, Youn JH, Kim WK

  • KMID: 1559380
  • Korean J Anat.
  • 2002 Oct;35(5):419-429.
Laminin, an extracellular matrix glycoprotein, is distributed in the basement membrane of renal glomerulus. Laminin has been demonstrated to regulate the development and differentiation of glomeruli and play an important...
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Expression of alphasmooth Muscle Actin, Aquaporin 1 and Renin after Blocking AT1 Receptor in Developing Renal Arterial System of Rat

Lim JM, Kim H, Jung JY, Lim SW, Kim WY, Han KH, Cha JH, Kim J

  • KMID: 2254452
  • Korean J Nephrol.
  • 2002 Jan;21(1):29-38.
BACKGROUND: Recent studies have demonstrated that renin, alphasmooth muscle actin(ASMA) and aquaporin-1(AQP1) participate in the development of renal arterial system. The components of the renin- angiotensin system have been shown...
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Safety and efficacy study of Hyzaar(R) in patients with hypertension: a community-based study

HIGH STUDY GROUP

  • KMID: 2252950
  • Korean J Med.
  • 2002 Jan;62(1):25-34.
BACKGROUND: This study was designed to evaluate efficacy and safety of losartan/hydrochlorothiazide combined tablet (Hyzaar(R)) under usual practice condition. METHODS: In HIGH (Hyzaar(R) In Group of Hypertensive patients) study, patients...
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