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Changes of Bax, Bcl-2, CCR-2, MCP-1, and TGF-β1 genes in the left ventricle of spontaneously hypertensive rat after losartan treatment

Lee H, Kim KC, Hong YM

PURPOSE: Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by...
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Losartan Prevents Maladaptive Auditory-Somatosensory Plasticity After Hearing Loss via Transforming Growth Factor-β Signaling Suppression

Mun SK, Han KH, Baek JT, Ahn SW, Cho HS, Chang MY

OBJECTIVES: Hearing loss disrupts the balance of auditory-somatosensory inputs in the cochlear nucleus (CN) of the brainstem, which has been suggested to be a mechanism of tinnitus. This disruption results...
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Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser¹¹⁷⁹ Dephosphorylation

Cho DH

BACKGROUND: Apart from its blood pressure-lowering effect by blocking the renin-angiotensin-aldosterone system, telmisartan, an angiotensin II type 1 receptor blocker (ARB), exhibits various ancillary effects including cardiovascular protective effects in...
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Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver

Cho KW, Cho DH

BACKGROUND: Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in...
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Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not?

Jonnalagadda VG, Choudhary , Matety VK

We have read the article “Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters...
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Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active-controlled, phase 4, randomized trial

Oh GC, Lee HY, Chung WJ, Youn HJ, Cho EJ, Sung KC, Chae SC, Yoo BS, Park CG, Hong SJ, Kim YK, Hong TJ, Choi DJ, Hyun MS, Ha JW, Kim YJ, Ahn Y, Cho MC, Kim SG, Shin J, Park S, Sohn IS, Kim CJ

BACKGROUND: Hypertension is a risk factor for coronary heart disease and stroke, and is one of the leading causes of death. Although over a billion people are affected worldwide, only...
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Angiotensin II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase

Ha TS, Park HY, Seong SB, Ahn HY

Angiotensin II (Ang II) induces the pathological process of vascular structures, including renal glomeruli by hemodynamic and nonhemodynamic direct effects. In kidneys, Ang II plays an important role in the...
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Microarray Analysis in Spontaneously Hypertensive Rat Heart after Losartan Treatment

Lee SW, Kim Y, Kim KC, Sohn S, Hong YM

OBJECTIVES: Spontaneously hypertensive rats (SHR) are frequently used as rat models of essential hypertension. The mechanism for the development of hypertension is complicated and it is unknown. The renin-angiotensin system...
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Changes of blood pressure, abdominal visceral fat tissue and gene expressions in fetal programming induced rat model after amlodipine-losartan combination treatment

Lee JH, Lee H, Lee SM, Kang PJ, Kim KC, Hong YM

BACKGROUND: There are a number of complications that can occur if there is under-nutrition during pregnancy followed by a period of rapid catch-up growth, including a higher chance of adult...
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Comparison of Inhibitory Effects between Enalapril and Losartan on Adrenal Catecholamine Secretion

Lim HJ, Koh YY, Lim DY

BACKGROUND: The present study was attempted to compare enalapril, an angiotensin-converting enzyme inhibitor with losartan an angiotensin II (Ang II) receptor blocker in the inhibitory effects on the secretion of...
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Validation of Tissue Microarrays for the Study of Immunosuppressive Agent-induced Nephrotoxicity

Lim BJ, Kim JH, Jeong HJ

BACKGROUND: Tissue microarray analysis (TMA) is a high-throughput method for histologic evaluation, immunohistochemistry, and in situ hybridization using paraffin embedded tissue. Despite its high efficiency as an experimental tool, TMA...
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An Angiotensin Receptor Blocker Prevents Arrhythmogenic Left Atrial Remodeling in a Rat Post Myocardial Infarction Induced Heart Failure Model

Kim HS, No CW, Goo SH, Cha TJ

This study investigated the role of angiotensin II receptor blocker in atrial remodeling in rats with atrial fibrillation (AF) induced by a myocardial infarction (MI). MIs were induced by a...
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Preventive Effects of the Angiotensin-II Receptor Blocker on Atrial Remodeling in an Ischemic Heart Failure Model of Rats

Yoon N, Kim KH, Park KH, Sim DS, Youn HJ, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC

BACKGROUND AND OBJECTIVES: It is widely known that angiotensin-II receptor blockers (ARBs) have reverse remodeling effects in atrium. Although atrial fibrillation is frequent in ischemic heart failure clinically, experiments to...
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Simvastatin and Losartan Differentially and Synergistically Inhibit Atherosclerosis in Apolipoprotein E-/- Mice

Lee BS, Choi JY, Kim JY, Han SH, Park JE

BACKGROUND AND OBJECTIVES: Since statins and angiotensin receptor blockers are a frequently prescribed combination in patients with atherosclerotic cardiovascular diseases, we tested the interactive effects of simvastatin and losartan on...
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Dexmedetomidine and remifentanil in the perioperative management of an adolescent undergoing resection of pheochromocytoma: A case report

Jung JW, Park JK, Jeon SY, Kim YH, Nam SH, Choi YG, Bang SR

A 15-year-old adolescent with unilateral multiple adrenal pheochromocytoma had an episode of subcortical intracerebral hemorrhage and seizure 6 weeks before the surgery. He was pretreated with terazosin, losartan, atenolol and...
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Changes of Gene Expressions in Spontaneously Hypertensive Rat Model After Losartan Treatment

Cha JH, Lee HR, Kim KC, Cho MS, Hong YM

BACKGROUND AND OBJECTIVES: The renin angiotensin system seems to play an important role in the development of cardiac and vascular hypertrophy in hypertension. The changes in pathology, and gene expressions...
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Hypertensive Heart Failure Associated with Middle Aortic Syndrome Reversed Dramatically by Endovascular Management

Kim W, Park CS, Kim HJ, Kim KH, An HM, Kim YH, Lim CH, Kang WY, Hwang SH, Kim W

A 42-year-old male patient presented with refractory hypertension and congestive heart failure. He had taken hydrochlorthiazide 50 mg, carvedilol 25 mg, diltiazem 180 mg, and losartan 100 mg per day....
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A Case of Licorice-Induced Hypokalemic Rhabdomyolysis in a Patient Using a Diuretic Drug

Park KA, Seok SJ, Kim SJ, Gil HW, Yang JO, Lee EY, Hong SY

  • KMID: 2258900
  • Korean J Med.
  • 2011 Jun;80(Suppl 2):S258-S262.
Glycyrrhizic acid is a component of licorice. It can cause hypokalemia through the inhibition of 11beta-hydroxysteroid dehydrogenase. The severity of symptoms depends on the dose and duration of licorice intake,...
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Effects of Spironolactone and Losartan on Diabetic Nephropathy in a Type 2 Diabetic Rat Model

Lee MY, Shim MS, Kim BH, Hong SW, Choi R, Lee EY, Nam SM, Kim GW, Shin JY, Shin YG, Chung CH

BACKGROUND: While there is an evidence that the anti-inflammatory properties of spironolactone can attenuate proteinuria in type 2 diabetes, its effects on vascular endothelial growth factor (VEGF) expression in diabetic...
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Effects of Losartan Administration on Uric acid Transporters in Rat Kidney

Kim S, Lee CH, Kang CM, Kim GH

  • KMID: 2012309
  • J Korean Soc Hypertens.
  • 2010 Jun;16(2):19-27.
BACKGROUND: Losartan, an angiotensin II receptor blockade, has been reported to decrease the serum uric acid level through its uricosuric action. However, the mechanism by which losartan affects renal handling...
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