- ACE Inhibitors and Losartan in the Managerment of Hypertesion
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Ryoo UH
- KMID: 1894743
- Korean Circ J.
- 1998 Jan;28(1):5-7.
- doi: 10.4070/kcj.1998.28.1.5
No abstract available. -
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- Losartan Inhibits Vascular Smooth Muscle Cell Proliferation through Activation of AMP-Activated Protein Kinase
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Kim JE, Choi HC
- KMID: 2071697
- Korean J Physiol Pharmacol.
- 2010 Oct;14(5):299-304.
- doi: 10.4196/kjpp.2010.14.5.299
Losartan is a selective angiotensin II (Ang II) type 1 (AT1) receptor antagonist which inhibits vascular smooth muscle cells (VSMCs) contraction and proliferation. We hypothesized that losartan may prevent cell... -
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- The Antihypertensive Efficacy, Safety, and Tolerability of Losartan Versus Fosinopril in Patients with Hypertension
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Park DG, Lee MM, Chai IH, Rhee MY, Lee HJ, Kim HS, Kim CH, Sohn DW, Oh BH, Park YB, Choi YS
- KMID: 1894745
- Korean Circ J.
- 1998 Jan;28(1):13-26.
- doi: 10.4070/kcj.1998.28.1.15
BACKGROUND: Losartan potassium, an orally active, highly selective AT (1) angiotensin II receptor inhibitor, effectively reduces blood pressure by directly blocking receptors. The purpose of this study is to compare... -
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- Simvastatin and Losartan Differentially and Synergistically Inhibit Atherosclerosis in Apolipoprotein E-/- Mice
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Lee BS, Choi JY, Kim JY, Han SH, Park JE
- KMID: 2225004
- Korean Circ J.
- 2012 Aug;42(8):543-550.
- doi: 10.4070/kcj.2012.42.8.543
BACKGROUND AND OBJECTIVES: Since statins and angiotensin receptor blockers are a frequently prescribed combination in patients with atherosclerotic cardiovascular diseases, we tested the interactive effects of simvastatin and losartan on... -
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- Effects of Losartan Administration on Uric acid Transporters in Rat Kidney
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Kim S, Lee CH, Kang CM, Kim GH
- KMID: 2012309
- J Korean Soc Hypertens.
- 2010 Jun;16(2):19-27.
BACKGROUND: Losartan, an angiotensin II receptor blockade, has been reported to decrease the serum uric acid level through its uricosuric action. However, the mechanism by which losartan affects renal handling... -
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- Spectral Analysis of Blood Pressure and Heart Rate Variability during Hemorrhage after Losartan Administration into the Lateral Ventricle
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Lee DW, Kim KS, Kim HJ, Lee WJ
- KMID: 1894776
- Korean Circ J.
- 1997 Dec;27(12):1341-1349.
- doi: 10.4070/kcj.1997.27.12.1341
This study was aimed to elucidate the effect of intracerebroventricular losartan administration on arterial pressure regulation during hemorrhage in rats by power spectral analysis of blood pressure and heart rate... -
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- Safety and efficacy study of Hyzaar(R) in patients with hypertension: a community-based study
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HIGH STUDY GROUP
- KMID: 2252950
- Korean J Med.
- 2002 Jan;62(1):25-34.
BACKGROUND: This study was designed to evaluate efficacy and safety of losartan/hydrochlorothiazide combined tablet (Hyzaar(R)) under usual practice condition. METHODS: In HIGH (Hyzaar(R) In Group of Hypertensive patients) study, patients... -
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- The Clinical Effects of Losartan (Cozaar) on Hypertensive Patients
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Kim NH, Jeong MH, Park WS, Kim SH, Kim JW, Cho JH, Ahn YK, Kim NH, Park JH, Cho JG, Park JC, Kang JC
- KMID: 2093654
- Korean Circ J.
- 1998 Aug;28(8):1299-1306.
- doi: 10.4070/kcj.1998.28.8.1299
BACKGROUND: Losartan potassium, one of an orally active, selective type 1 angiotensin II receptor blocker, has been introduced recently as an antihypertensive agent. METHOD: Losartan, angiotensin II receptor blocker, was... -
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- A Clinical Evaluation on the Antihypertensive Effect of Losartan(Cozaar(R))
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Park SH, Park YM
- KMID: 1964823
- Ewha Med J.
- 1999 Dec;22(4):219-223.
- doi: 10.12771/emj.1999.22.4.219
BACKGROUND: Although angiotensin converting enzyme inhibitors have provided plausible effect for the management of hypertension and congestive heart failure, it does have drawbacks such as dry cough in as much... -
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- Effect of Angiotensin II Receptor Blockers in Proteinuric IgA Nephropathy
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Noh JH, Hwang YC, Lee TW, Ihm CG
- KMID: 2079164
- Korean J Nephrol.
- 2001 Mar;20(2):277-282.
Whether immunosuppressive therapy may have beneficial effects in the treatment of IgA nephropathy remains controversial. ACE inhibitor or angiotensin II receptor antagonist(AIIA) are suggested to reduce urinary protein excretion(Up) in... -
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- Effects of Centrally Administered Losartan on Deoxycorticosterone-salt Hypertension Rats
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Park CG, Leen FH
- KMID: 2157561
- J Korean Med Sci.
- 2001 Oct;16(5):553-557.
- doi: 10.3346/jkms.2001.16.5.553
To investigate whether brain AT1 receptor stimulation contributes as a hypertensive mechanism to deoxycorticosterone acetate (DOCA)-salt hypertension, losartan (1 mg/4l) or artificial cerebrospinal fluid (aCSF) was injected into the lateral... -
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- Effects of Angiotensin II on ZO-1 in Glomerular Epithelial Cells
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Koo HH, Ha TS
- KMID: 2307207
- Korean J Nephrol.
- 2007 Sep;26(5):516-525.
PURPOSE: Angiotensin II plays a potent role in renal injury not only by vasoconstrictive effects but also by biochemical effects. We investigated the effect of angiotensin II on ZO-1 (zonular... -
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- Microarray Analysis in Spontaneously Hypertensive Rat Heart after Losartan Treatment
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Lee SW, Kim Y, Kim KC, Sohn S, Hong YM
- KMID: 2171364
- Ewha Med J.
- 2016 Apr;39(2):45-50.
- doi: 10.12771/emj.2016.39.2.45
OBJECTIVES: Spontaneously hypertensive rats (SHR) are frequently used as rat models of essential hypertension. The mechanism for the development of hypertension is complicated and it is unknown. The renin-angiotensin system... -
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- The Role of Angiotensin Converting Enzyme inhibitor in Ventricular Remodeling after Experimental Nontransmural Myocardial Infarction- Effects on Transforming Growth Factor-beta 1 Expression
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Youn TJ, Kim SY, Kim HS, Kim EJ, Kim SY, Chung EJ, Seo JW, Oh BH
- KMID: 2298008
- Korean Circ J.
- 1998 Sep;28(9):1590-1599.
- doi: 10.4070/kcj.1998.28.9.1590
BACKGROUND:With the application of early reperfusion by thrombolysis after acute MI, the importance of nontransmural infarction is increasing. We evaluated 1) the changes of LV dimension, LV fibrosis and transforming... -
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- Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not?
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Jonnalagadda VG, Choudhary , Matety VK
- KMID: 2404112
- Clin Hypertens.
- 2017 ;23(1):27.
- doi: 10.1186/s40885-017-0082-0
We have read the article “Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters... -
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- Effect of Central Losartan on DOCA-Salt Hypertension Rats
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Lee SJ, Park CG, Park JS, Kim EJ, Shin SH, Jin DG, Ahn JC, Seo HS, Oh DJ, Ro YM
- KMID: 1938858
- Korean Circ J.
- 2004 Jan;34(1):84-91.
- doi: 10.4070/kcj.2004.34.1.84
BACKGROUND: The purpose of this study was to investigate whether brain AT1 receptor stimulation contributes as a hypertensive mechanism to deoxycorticosterone acetate (DOCA)-salt hypertension. METHODS: 1) Acute injection:Losartan (1 mg/4... -
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- Changes of Bax, Bcl-2, CCR-2, MCP-1, and TGF-β1 genes in the left ventricle of spontaneously hypertensive rat after losartan treatment
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Lee H, Kim KC, Hong YM
- KMID: 2447196
- Korean J Pediatr.
- 2019 Mar;62(3):95-101.
- doi: 10.3345/kjp.2018.06856
PURPOSE: Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by... -
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- Inhibitory Effect of Angiotensin II Receptor Antagonist on the Contraction and Growth of Hepatic Stellate Cells
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Baik SK, Jo HS, Suk KT, Kim JM, Lee BJ, Choi YJ, Kim HS, Lee DK, Kwon SO, Lee KI, Cha SK, Park KS, Kong ID
- KMID: 772535
- Korean J Gastroenterol.
- 2003 Aug;42(2):134-141.
BACKGROUNDS/AIMS: This study aimed to investigate the effects of angiotensin II (ANG II) and its receptor antagonist (losartan) on the contraction and growth of HSCs. METHODS: HSCs were isolated... -
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- Comparison of Inhibitory Effects between Enalapril and Losartan on Adrenal Catecholamine Secretion
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Lim HJ, Koh YY, Lim DY
- KMID: 2196750
- J Korean Soc Hypertens.
- 2014 Jun;20(2):51-67.
- doi: 10.5646/jksh.2014.20.2.51
BACKGROUND: The present study was attempted to compare enalapril, an angiotensin-converting enzyme inhibitor with losartan an angiotensin II (Ang II) receptor blocker in the inhibitory effects on the secretion of... -
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- Changes of Gene Expressions in Spontaneously Hypertensive Rat Model After Losartan Treatment
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Cha JH, Lee HR, Kim KC, Cho MS, Hong YM
- KMID: 2224976
- Korean Circ J.
- 2012 Nov;42(11):761-768.
- doi: 10.4070/kcj.2012.42.11.761
BACKGROUND AND OBJECTIVES: The renin angiotensin system seems to play an important role in the development of cardiac and vascular hypertrophy in hypertension. The changes in pathology, and gene expressions... -
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