Clin Hypertens.  2017 ;23(1):27. 10.1186/s40885-017-0082-0.

Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not?

• Jonnalagadda VG
• Choudhary
• Matety VK

• KMID: 2404112
• DOI: http://doi.org/10.1186/s40885-017-0082-0

Abstract

We have read the article "Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial" by GC Oh., et al. and found it quite interesting to learn the testing of effectiveness between amlodipine and hydrochlorothiazide in combination with losartan. After 4 weeks of therapy, non-responders were exposed for dose titration of losartan/amlodipine 100/5 mg daily or losartan/hydrochlorothiazide 100/25 mg daily. However, authors didn't increase in the amlodipine dose from 5 to 10 mg from randomization. However, as per literature both drugs are non-significant in their blood pressure lowering effect. The clarification on above point will further allay the efficacy concerns of clinicians and result in wider usage of future published data.

Keyword

Hypertension; Calcium channel blockers; Thiazide diuretics; ARB blockers

MeSH Terms

Amlodipine*
Blood Pressure
Calcium Channel Blockers
Calcium Channels
Diuretics
Hemodynamics
Humans
Hydrochlorothiazide*
Hypertension
Losartan
Random Allocation
Receptors, Angiotensin
Sodium Chloride Symporter Inhibitors
Amlodipine
Calcium Channel Blockers
Calcium Channels
Diuretics
Hydrochlorothiazide
Losartan
Receptors, Angiotensin
Sodium Chloride Symporter Inhibitors