Clin Hypertens.  2018 ;24(1):4. 10.1186/s40885-018-0089-1.

Chlorthalidone, not hydrochlorothiazide, is the right diuretic for comparison

• Mehta RT
• Pareek A
• Purkait I

• KMID: 2434258
• DOI: http://doi.org/10.1186/s40885-018-0089-1

Abstract

We have read the study design "Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial" by Oh GC, et al. with interest. The authors aim to compare the efficacy of amlodipine or hydrochlorothiazide (HCTZ) with an ARB. However, we wish to highlight that chlorthalidone (CTD) is the evidence-based and recommended anti-hypertensive diuretic, and should replace HCTZ in the trial to effectively compare efficacy against the CCB amlodipine.

Keyword

Chlorthalidone; Hydrochlorothiazide; Amlodipine; Hypertension; Thiazide diuretics; Calcium channel blockers

MeSH Terms

Amlodipine
Blood Pressure
Calcium Channel Blockers
Calcium Channels
Chlorthalidone*
Diuretics
Hemodynamics
Humans
Hydrochlorothiazide*
Hypertension
Receptors, Angiotensin
Sodium Chloride Symporter Inhibitors
Amlodipine
Calcium Channel Blockers
Calcium Channels
Chlorthalidone
Diuretics
Hydrochlorothiazide
Receptors, Angiotensin
Sodium Chloride Symporter Inhibitors