Korean J Nephrol.  2011 Sep;30(5):459-467.

Direct Vascular Actions of Indapamide in Aorta from Renal Hypertensive Rats

• Choi S
• Whi HW
• Lee MJ
• Jun JY
• Kim HL
• Chung JH
• Shin HR
• Oh HJ
• Yeum CH

Abstract

PURPOSE
Thiazide diuretics exert their hypotensive efficacy through a combined vasodilator and diuretic effect. The present study was conducted to assess the inhibitory effect of thiazide diuretic, hydrochlorothiazide, and the thiazide-like diuretics, indapamide and chlorthalidone on contractile responses to norepinephrine and arginine vasopressin in aortic rings from 2K1C renal hypertensive and sham-clipped normotensive rats.
METHODS
2K1C hypertension was made by clipping the left renal artery and age-matched control rats received a sham treatment. Changes in the tension of aortic ring preparations were measured isometrically.
RESULTS
Indapamide inhibits the contractile responses to norepinephrine and vasopressin in aortic rings from 2K1C rats, while it did not modify in control rats. The inhibitory effect of indapamide was abolished by endothelium removal. Hydrochlorothiazide or chlorthalidone did not affect the vasoconstriction induced by norepinephrine and vasopressin either in sham or in 2K1C hypertensive rats.
CONCLUSION
These results suggest that indapamide inhibits the contractile responses to norepinephrine and vasopressin via an endothelium-dependent mechanism in 2K1C renal hypertension.

Keyword

Thiazide diuretics; Vasodilatation; Renal hypertension

MeSH Terms

Animals
Aorta
Arginine Vasopressin
Chlorthalidone
Diuretics
Endothelium
Hydrochlorothiazide
Hypertension
Hypertension, Renal
Indapamide
Norepinephrine
Placebos
Rats
Renal Artery
Salicylamides
Sodium Chloride Symporter Inhibitors
Vasoconstriction
Vasodilation
Vasopressins
Arginine Vasopressin
Chlorthalidone
Diuretics
Hydrochlorothiazide
Indapamide
Norepinephrine
Placebos
Salicylamides
Sodium Chloride Symporter Inhibitors
Vasopressins