Korean Circ J.  2012 Sep;42(9):614-617. 10.4070/kcj.2012.42.9.614.

Urinary Levels of 8-Iso-Prostaglandin F2alpha and 8-Hydroxydeoxyguanine as Markers of Oxidative Stress in Patients With Coronary Artery Disease

• Kim JY
• Lee JW
• Youn YJ
• Ahn MS
• Ahn SG
• Yoo BS
• Lee SH
• Yoon J
• Choe KH

• KMID: 2297892
• DOI: http://doi.org/10.4070/kcj.2012.42.9.614

Abstract

BACKGROUND AND OBJECTIVES
The objective of this study was to determine if urinary levels of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) and 8-hydroxydeoxyguanine (8-OHdG) could be used as markers of the oxidative stress in significant coronary artery disease (CAD).
SUBJECTS AND METHODS
We conducted a case-control study in 104 subjects assessed by coronary angiography with the following diagnoses: 35 consecutive cases of significant CAD and 69 cases of non-CAD with stable angina. We compared the urinary levels of 8-iso-PGF 2alpha and 8-OHdG, as measured by immunoassay between the 2 groups.
RESULTS
History of hypertension was significantly higher and high density lipoprotein-cholesterol level significantly lower in the CAD group compared with those in the non-CAD group. Median levels of 8-iso-PGF2alpha were significantly higher in the CAD group compared with the non-CAD group (9.2 vs. 6.0 ng/mg, p=0.001). There were no significant differences in 8-OHdG values between the 2 groups. The odds ratio of 8-iso-PGF2alpha for CAD in the highest tertile compared with that in the lowest tertile was 7.39 (95% confidence interval; 1.71-31.91). There was no significant difference in median values of 8-iso-PGF2alpha between single- and multi-vessel CAD.
CONCLUSION
Urinary 8-iso-PGF 2alpha was independently associated with significant CAD in this case-control study.

Keyword

Oxidative stress; Coronary artery disease

MeSH Terms

Angina, Stable
Case-Control Studies
Coronary Angiography
Coronary Artery Disease
Coronary Vessels
Dinoprost
Guanine
Humans
Hypertension
Immunoassay
Odds Ratio
Oxidative Stress
Dinoprost
Guanine

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