Clin Psychopharmacol Neurosci.  2023 May;21(2):370-376. 10.9758/cpn.2023.21.2.370.

Serum Levels of 8-Iso-Prostaglandin F2α and Raftlin in Patients with Generalized Anxiety Disorder

• Hursitoğlu O
• Kurutas EB

• KMID: 2542944
• DOI: http://doi.org/10.9758/cpn.2023.21.2.370

Abstract

Objective
Although there are neurobiological studies of patients with generalized anxiety disorder (GAD), the topic is still open to research. Lipid peroxidation can generate new molecular signal sequences by altering protein amounts and activity. 8-Iso-Prostaglandin F2α (8-iso-PGF2α) is known to be an important lipid peroxidation marker. Raftlin, which is defined as a major lipid raft protein, is important for the regulation of signal transduction and inflammatory processes.
Methods
Our aim in this study was to compare the 8-iso-PGF2α and Raftlin levels of forty patients diagnosed with GAD and 40 healthy controls (age-sex and body mass index-matched).
Results
In the present study, increased serum 8-iso-PGF2α and Raftlin levels were found in patients with GAD compared to healthy controls.
Conclusion
To our knowledge, this is the first study to examine 8-iso-PGF2α and Raftlin levels in patients with GAD. These results expand our knowledge of oxidative stress and inflammatory processes in patients with GAD. Our study should be considered preliminary and further studies should be performed with larger sample groups comparing values before and after treatment.

Keyword

Inflammation; Lipids; Diagnosis; Oxidative stress; Cell membrane