Korean J Thorac Cardiovasc Surg.  1999 Nov;32(11):971-977.

Sequential changes of Interleukin-6 , Tumor Necrosis Factor-alpha, and Troponin-T During Open Heart Surgery with Cardiopulmonary Bypass

• Yu JY
• Choi SC
• Kwak GO
• Choi GR
• Kim SM
• Jo KH

Abstract

BACKGROUND: Immunologic and inflammatory responses of cardiopulmonary bypass(CPB) influence postoperative mortality and morbidity with multiple organ injury. It has been reported that ischemia/reperfusion induced-myocardial injury during CPB is causative of release of inflammatory cytokines such as interleukin-6(IL-6) and tumor necrosis factor-alpha (TNF-alpha). The purpose of this study was to detect the time course of the activated cytokine and troponin-T(TnT), and to examine the correlation between such parameters during CPB. MATERIAL AND METHOD: The serial samples were collected from arterial blood via radial arterial catheter in 23 patients who are underwent open heart surgery (OHS) with CPB, the IL-6, TNF-alpha and TnT were checked. RESULT: (1) IL-6, TNFalpha- and TnT concentration increased significantly during CPB with a peaking level of CPB-off (p 0.05). (2) IL-6 had highly positive correlation with aortic cross clamping time and total bypass time(r=0.80, 0.78; p 0.05, respectively). (3) There was no correlation among IL-6, TNF-alpha and TnT.
CONCLUSION
In conclusion, these data showed that elevated production of serum IL-6 during CPB was attributable to ischemia/reperfusion induced-myocardial damage. IL-6 will become a new and sensitive biological marker in assessment of myocardial damage during OHS with CPB. However, further studies will be needed to apply IL-6 in more patient population.

Keyword

Cardiopulmonary Bypass; Interleukin-6; Tumor Necrosis Factor

MeSH Terms

Biomarkers
Cardiopulmonary Bypass*
Catheters
Constriction
Cytokines
Heart*
Humans
Interleukin-6*
Mortality
Thoracic Surgery*
Trinitrotoluene
Troponin T*
Tumor Necrosis Factor-alpha*
Cytokines
Interleukin-6
Trinitrotoluene
Troponin T
Tumor Necrosis Factor-alpha