Korean J Anesthesiol.  2013 Apr;64(4):334-340. 10.4097/kjae.2013.64.4.334.

Effect of ulinastatin on perioperative organ function and systemic inflammatory reaction during cardiac surgery: a randomized double-blinded study

• Song J
• Park J
• Kim JY
• Kim JD
• Kang WS
• Muhammad H
• Kwon MY
• Kim SH
• Yoon TG
• Kim TY
• Chung JW

• KMID: 2299371
• DOI: http://doi.org/10.4097/kjae.2013.64.4.334

Abstract

BACKGROUND
This study evaluated the efficacy of ulinastatin for attenuating organ injury and the release of proinflammatory cytokines due to cardiopulmonary bypass (CPB) during cardiac surgery.
METHODS
Patients undergoing valvular heart surgery employing CPB were assigned to receive either ulinastatin (group U, n = 13) or a placebo (group C, n = 11) before the commencement of CPB. Hemodynamic data, parameters of major organ injury and function, and proinflammatory cytokines were measured after the induction of anesthesia (T1), after CPB (T2), at the end of anesthesia (T3), and at 24 hours after surgery (POD).
RESULTS
The demographic data, CPB duration, and perioperative transfusions were not different between the groups. PaO2/FiO2 in group U was significantly higher than that in group C at T3 (3.8 +/- 0.8 vs. 2.8 +/- 0.7, P = 0.005) and at POD (4.0 +/- 0.7 vs. 2.8 +/- 0.7, P < 0.001). Creatine kinase-MB at POD in group U was significantly lower than that in group C (17.7 +/- 8.3 vs. 33.7 +/- 22.1, P = 0.03), whereas troponin I at POD was not different between the groups. Creatinine clearance and the extubation time were not different between the groups at POD. The dopamine infusion rate during the post-CPB period in group U was significantly lower than that in group C (1.6 +/- 1.6 vs. 5.5 +/- 3.3 microg/kg/min, P = 0.003). The interleukin-6 and tumor necrosis factor-alpha concentrations at T1, T2, and T3 as well as the incidences of postoperative cardiac, pulmonary and kidney injuries were not different between the groups.
CONCLUSIONS
Ulinastatin pretreatment resulted in an improved oxygenation profile and reduced inotropic support, probably by attenuating the degree of cardiopulmonary injury; however, it did not reduce the levels of proinflammatory cytokines.

Keyword

Cardiopulmonary bypass; Inflammatory; Organ; Ulinastatin

MeSH Terms

Anesthesia
Cardiopulmonary Bypass
Creatine
Creatinine
Cytokines
Dopamine
Glycoproteins
Hemodynamics
Humans
Incidence
Interleukin-6
Kidney
Oxygen
Thoracic Surgery
Troponin I
Tumor Necrosis Factor-alpha
Creatine
Creatinine
Cytokines
Dopamine
Glycoproteins
Interleukin-6
Oxygen
Troponin I
Tumor Necrosis Factor-alpha