Korean J Thorac Cardiovasc Surg.  2006 May;39(5):366-375.

The Clinical Effect of Administration of Magnesium Sulfate in Cardiac Surgery

• Bang JH
• Moon SM
• Kim SH
• Cho KJ
• Choi PJ
• Woo JS

Abstract

BACKGROUND: Hypomagnesemia is a common complication after cardiac surgery with cardiopulmonary bypass. The purpose of this study was to assess the clinical beneficial effect of administration of magnesium sulfate in cardiac surgery. MATERIAL AND METHOD: Thirty five patients scheduled for elective cardiac surgery were randomly assigned to magnesium group (n=20) which received magnesium sulfate in priming solution (1 g) and cardioplegic solution (1 g) or control group (n=15) which did not receive it. Arterial blood samples were drawn for measuring Mg++ and electrolytes contents, blood gas analysis, CBC, total protein, albumin, blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10), creatine phosphokinase (CpK), creatine kinase-MB (CK-MB), lactate dehydrogenase(LDH), troponin-I (TNI), prothrombin time (PT) and activated pratial thromboplastin time level (aPTT). Venous blood samples were drawn before and after the operation for measuring activated clotting time level (ACT). RESULT: Mg++ levels in magensium group were higher than those of control group at intraoperative and postoperative periods (p<0.05). dysrhythmias were lower in magnesium group (8 cases out of 17 patients, 46.4%) than in control group (10 cases out of 10, 100%, p=0.050).
CONCLUSION
These results showed that administration of low dose magnesium sulfate during cardiac surgery prevented hypomagnesemia and lowered incidence of dysrhythmia.

Keyword

Heart surgery; Cardiopulmonary bypass; Magnesium

MeSH Terms

Alanine Transaminase
Aspartate Aminotransferases
Bilirubin
Blood Gas Analysis
Blood Urea Nitrogen
Cardioplegic Solutions
Cardiopulmonary Bypass
Creatine
Creatine Kinase
Creatinine
Electrolytes
Humans
Incidence
Interleukin-10
Interleukin-6
Lactic Acid
Magnesium Sulfate*
Magnesium*
Postoperative Period
Prothrombin Time
Thoracic Surgery*
Thromboplastin
Troponin I
Tumor Necrosis Factor-alpha
Alanine Transaminase
Aspartate Aminotransferases
Bilirubin
Cardioplegic Solutions
Creatine
Creatine Kinase
Creatinine
Electrolytes
Interleukin-10
Interleukin-6
Lactic Acid
Magnesium
Magnesium Sulfate
Thromboplastin
Troponin I
Tumor Necrosis Factor-alpha