Korean J Psychopharmacol.  2003 Dec;14(4):347-353.

Dopamine Transporter Gene Polymorphism Association between ADHD Patients and the Parents Group

• Lim MH
• Yu SH
• Paik KC
• Cho SC
• Kim HW
• Yoon DY

Abstract

OBJECTIVES
Attention deficity hyperactive disorder is known to be a disease with a high genetic trait. Recently the relationship between alleles frequency distribution and ADHD has been actively researched. In Korea, the relationship between the genetic type and alleles for dopamine transporter gene has been studied in ADHD patients. METHODS: Thirty five patients diagnosed with ADHD according to the DSM-IV diagnostic criteria were selected for study. The diagnosis and clinical features were confirmed by korean version Child behavior check list, korean version Conner's parent rating scale, Attention deficit Diagnostic System, korean version Spielberger state-trait anxiety scale etc. For the control group, the parents of patients were chosen. Blood samples were taken from the 105 subjects. DNA was extracted from blood lymphocytes, PCR was performed for dopamine transporter gene. RESULTS AND CONCLUSION: In comparing the ADHD transmitted group and the not transmitted group, significant difference was seen between the DAT1 genetic type and alleles distribution. As a result, it is viewed that there is relationship between ADHD and the dopamine transporter gene. Follow up studies with larger patient or pure subgroups are expected.

Keyword

Attention deficit hyperactivity disorder; Dopamine transporter gene; Polymorphism

MeSH Terms

Alleles
Anxiety
Attention Deficit Disorder with Hyperactivity
Child
Child Behavior
Diagnosis
Diagnostic and Statistical Manual of Mental Disorders
DNA
Dopamine Plasma Membrane Transport Proteins*
Dopamine*
Follow-Up Studies
Humans
Korea
Lymphocytes
Parents*
Polymerase Chain Reaction
DNA
Dopamine
Dopamine Plasma Membrane Transport Proteins