J Korean Acad Child Adolesc Psychiatry.
2010 Feb;21(1):23-30.
Case-Control Association Study of the Norepinephrine Transporter Gene Polymorphism in Children with ADHD
- Affiliations
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- 1Department of Psychiatry, Bundang Jesaeng Hospital, Seongnam, Korea.
- 2Department of Psychiatry, Bundang CHA Hospital, School of Medicine, CHA University, Seongnam, Korea.
- 3Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, College of Medicine, Yonsei University, Seoul, Korea.
- 4Department of Psychiatry, Hallym University College of Medicine, Anyang, Korea. honghj88@gmail.com
Abstract
OBJECTIVES
This study aimed to examine the association between norepinephrine transporter gene (SLC6A2) polymorphisms and attention-deficit hyperactivity disorder (ADHD) and to examine the relationship between the genotypes and allele variants of SLC6A2 and results of the Korean version of the parent ADHD rating scale (K-ARS).
METHODS
We examined the association between ADHD and norepinephrine transporter gene polymorphism using DNA from 137 Korean children with ADHD and 120 normal controls. We compared the genotype distributions and allele frequencies of SLC6A2 polymorphism between the control group and the ADHD group. Then, we correlated the children's K-ARS mean totals, inattention scores, and hyperactivity/impulsivity scores with the genotypes and alleles for each SLC6A2 polymorphism.
RESULTS
There were no significant differences in genotype and allele distribution for each SLC6A2 polymorphism, as shown by the Chi-square test (p>.01). There was a trend toward a difference in allele frequency in rs 5568, but it was not statistically significant after adjusting for multiple comparisons (p=.048). Also, there were no significant differences in K-ARS scores according to the genotypes and alleles for the SLC6A2 polymorphisms.
CONCLUSION
Our study found no significant evidence of an association between SLC6A2 polymorphisms and ADHD.
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