J Korean Acad Child Adolesc Psychiatry.  2014 Jun;25(2):82-88. 10.5765/jkacap.2014.25.2.82.

Association of Norepinephrine Transporter Gene and Side Effects of Osmotic-Release Oral System Methylphenidate in Attention-Deficit Hyperactivity Disorder

• Song J
• Hong HJ
• Lee BO
• Yook KH

• KMID: 2291606
• DOI: http://doi.org/10.5765/jkacap.2014.25.2.82

Abstract

OBJECTIVES
The aim of our study was to investigate association of norepinephrine transporter gene (SLC6A2) polymorphism and side effects of osmotic-release oral system methylphenidate (OROS MPH) in children with attention-deficit hyperactivity disorder (ADHD).
METHODS
We recruited drug naive children with ADHD (N=97). We administered OROS MPH by tolerable dosage. At week 8 of treatment, parents completed the Barkley's side effect rating scale. We analyzed two SLC6A2 single nucleotide polymorphisms (SNPs), rs192303 and rs3785143, with blood of subjects. We compared the frequency and severity of each side effect among SLC6A2 genotypes of 2 SNPs.
RESULTS
In the analysis of frequency of each side effect, irritability differed according to rs192303 and rs3785143 genotype. In comparisons of severity, talking less and disinterest differed according to rs192303 genotype. In the case of rs3785143, severities of disinterest and irritability were involved with genotype.
CONCLUSION
Side effects of OROS MPH showed an association with SLC6A2 genotype.

Keyword

ADHD; SLC6A2; OROS Methylphenidate; Side Effects

MeSH Terms

Child
Genotype
Humans
Methylphenidate*
Norepinephrine Plasma Membrane Transport Proteins*
Parents
Polymorphism, Single Nucleotide
Methylphenidate
Norepinephrine Plasma Membrane Transport Proteins