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Early Treatment Response of Bupropion SR in Smoking Cessation according to Genetic Polymorphism and Temperamental Characteristics

Lee YS, Kim SY, Han DH, Min KJ, Na C

  • KMID: 2287243
  • Korean J Psychopharmacol.
  • 2006 Mar;17(2):219-228.
OBJECTIVE: Bupropion is an antidepressant with proven efficacy for smoking cessation, however the response rate is some limited. With this background, the authors investigated the difference of early bupropion response...
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Central Nervous System Drug Evaluation Using Positron Emission Tomography

Sekine M, Maeda J, Shimada H, Nogami T, Arakawa R, Takano H, Higuchi M, Ito H, Okubo Y, Suhara T

  • KMID: 2171280
  • Clin Psychopharmacol Neurosci.
  • 2011 Apr;9(1):9-16.
In conventional pharmacological research in the field of mental disorders, pharmacological effect and dose have been estimated by ethological approach and in vitro data of affinity to the site of...
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Association between the Genetic Polymorphisms of the Biogenic Amine Transporters and the Antidepressant Responsiveness in Korean Depressed Patients

Kim DK, Kim EJ, Lim SW, Kim H

  • KMID: 2287338
  • Korean J Psychopharmacol.
  • 2003 Sep;14(3):274-283.
OBJECTIVE: Serotonin transporter (5-HTT) is a key synaptic regulator of serotonergic neurotransmission and a major site of action of most antidepressants. The functional polymorphism of 5-HTT gene is reported to...
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Neurobiology of Attention-Deficit/Hyperactivity Disorder and the Action Mechanism of OROS Methylphenidate

Koo YJ, Lee MS, Shin DW, Kim EJ, Kang JW, Cho SC

  • KMID: 2172663
  • J Korean Acad Child Adolesc Psychiatry.
  • 2012 Oct;23(Suppl):S5-S11.
This article is to review neurobiology of attention-deficit/hyperactivity disorder (ADHD) and pharmacological properties of Osmotic-Controlled Release Oral delivery System Methylphenidate (OROS MPH)(Concerta Oros(R)) in celebration of its one-decade clinical experiences...
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Altered expression of norepinephrine transporter and norepinephrine in human placenta cause pre-eclampsia through regulated trophoblast invasion

Na KH, Choi JH, Kim CH, Kim KS, Kim GJ

OBJECTIVE: We investigated the norepinephrine transporter (NET) expression in normal and pre-eclamptic placentas and analyzed the invasion activity of trophoblastic cells based on norepinephrine (NE)-NET regulation. METHODS: NET and NE expression...
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Case-Control Association Study of the Norepinephrine Transporter Gene Polymorphism in Children with ADHD

Song J, Yook KH, Lee SH, Kim SW, Lee MG, Hong HJ

  • KMID: 2291709
  • J Korean Acad Child Adolesc Psychiatry.
  • 2010 Feb;21(1):23-30.
OBJECTIVES: This study aimed to examine the association between norepinephrine transporter gene (SLC6A2) polymorphisms and attention-deficit hyperactivity disorder (ADHD) and to examine the relationship between the genotypes and allele variants...
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An Association Study between Various Monoamine Transporter Gene Polymorphisms and Treatment Response to Mirtazapine in Major Depression

Choi H, Lim SW, Kim SY, Kim H, Chung JW, Kim DK

  • KMID: 2287416
  • Korean J Psychopharmacol.
  • 2008 Sep;19(5):266-275.
OBJECTIVE: Genetic differences may contribute to the inter-individual differences in treatment response to antidepressants among patients suffering from major depression. This study investigated a possible association of various monoamine transporter...
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Association of Norepinephrine Transporter Gene and Side Effects of Osmotic-Release Oral System Methylphenidate in Attention-Deficit Hyperactivity Disorder

Song J, Hong HJ, Lee BO, Yook KH

OBJECTIVES: The aim of our study was to investigate association of norepinephrine transporter gene (SLC6A2) polymorphism and side effects of osmotic-release oral system methylphenidate (OROS MPH) in children with attention-deficit...
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Association Study between Norepinephrine Transporter Gene Polymorphism and Schizophrenia in a Korean Population

Choo M, Hwang JA, Jeon SW, Oh SY, Yoon HK, Lee HJ, Kim YK

OBJECTIVE: We aimed to investigate possible associations between three norepinephrine transporter gene (SLC6A2) single nucleotide polymorphisms (T182C, A3081T, and G1287A) and schizophrenia. Also, we investigated the relationships of those polymorphisms...
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Analysis of Association between Norepinephrine Transporter Gene Polymorphisms and Personality Traits of NEO-FFI in a Japanese Population

Narita S, Iwahashi K, Nagahori K, Numajiri M, Yoshihara , Ohtani N, Ishigooka

OBJECTIVE: Norepinephrine is an important chemical messenger that is involved in mood and stress in humans, and is reabsorbed by the norepinephrine transporter (NET). According to Cloninger's theory, the noradrenergic...
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Effects of Persisting Emotional Impact from Child Abuse and Norepinephrine Transporter Genetic Variation on Antidepressant Efficacy in Major Depression: A Pilot Study

Singh AB, Bousman CA, Ng CH, Byron K, Berk M

OBJECTIVE: Previous studies suggest child abuse and serotonergic polymorphism influence depression susceptibility and anti-depressant efficacy. Polymorphisms of the norepinephrine transporter (NET) may also be involved. Research in the area is...
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Effects of Atomoxetine on Hyper-Locomotive Activity of the Prenatally Valproate-Exposed Rat Offspring

Choi CS, Hong M, Kim KC, Kim JW, Yang SM, Seung H, Ko MJ, Choi DH, You JS, Shin CY, Bahn GH

A substantial proportion of patients with autism spectrum disorder (ASD) display hyperactivity as a comorbid symptom. Exposure to valproic acid (VPA) during pregnancy produces ASD-like core behavioral phenotypes as well...
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