J Korean Acad Child Adolesc Psychiatry.
2008 Feb;19(1):19-27.
Dopamine Transporter Gene and Dopamine D2, D3, D4 Receptor Gene Polymorphisms in Attention Deficit Hyperactivity Disorder
- Affiliations
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- 1Mind Feel Clinic, Daegu, Korea.
- 2Department of Anatomy, Keimyung University School of Medicine, Daegu, Korea.
- 3Department of Psychiatry, Keimyung University School of Medicine, Daegu, Korea. jung5301@dsmc.or.kr
Abstract
OBJECTIVES
The aim of this study was to examine the association of attention-deficit hyperactivity disorder (ADHD) in Korean populations with functional polymorphisms of six genes dopamine receptors (Ser311/Cys311 polymorphism, Taq1 A polymorphism, and Taq1 B polymorphism in DRD2, BalI polymorphism in DRD3, and promoter -521 C/T polymorphism and exon III 48 bp repeat polymorphism in DRD4) and one gene in dopamine transporter (DAT1).
METHODS
Participants were 58 children with ADHD and 110 control children. The genotypes were determined by PCR.
RESULTS
There was a statistically significant difference in genotype frequency of -521 C/T polymorphism within the promoter region of the DRD4 between two groups. Furthermore, in the male group, both genotype and allele frequencies showed statistically significant differences.
CONCLUSION
Findings of the study indicate that -521 C/T polymorphism in promoter region of DRD4 appears to be a possible candidate gene for ADHD in Korean population.
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