Korean J Psychopharmacol.  2004 Jun;15(2):196-205.

Association between Serotonin Transporter Polymorphism and the Effect of Atypical Antipsychotics on Serum Glucose and Lipids

• Park SH
• Kim MC
• Yoon SH
• Kong BG
• Kim YH

Abstract

OBJECTIVE
The author investigated the association between the genotype distribution of 5-HTTLPR and the effects of atypical antipsychotics on serum glucose and lipids in schizophrenic patients. METHODS: Study subjects were 66 schizophrenic patients taking atypical antipsychotics (risperidone, olanzapine, clozapine, quetiapine, zotepine). The control group consisted of 82 schizophrenic patients taking typical antipsychotics (haloperidol). All subjects were medicated for at least 12 weeks. The author examined serum fasting blood sugar (FBS), HbA1c, total cholesterol, triglyceride, and the genotype distribution of 5-HTTLPR in all subjects. The presence of the 5-HTTLPR gene was determined by using polymerase chain reaction of genomic DNA with primers flanking the promoter regions of the 5-HTT gene. Between group comparisons of the genotype distribution and the effects of antipsychotics on the serum glucose and lipid levels were performed by using score test for t-test, one way ANOVA, and chi-square test. RESULTS: There was a significant increase in FBS level in all patients taking atypical antipsychotics except for those treated with risperidone. However, there was no statistically significant correlation between 5-HTTLPR genotype distribution and the effect of atypical antipsychotics on FBS, HbA1c, total cholesterol, and triglyceride serum levels in schizophrenic patients. CONCLUSION: These results suggest that 5-HTTLPR polymorphism has no significant association with the effect of atypical antipsychotics on serum glucose and lipids in Korean schizophrenic patients.

Keyword

5-HTTLPR;Polymorphism; Schizophrenia; Atypical antipsychotics; Serum glucose; Serum lipid

MeSH Terms

Antipsychotic Agents*
Blood Glucose*
Cholesterol
Clozapine
DNA
Fasting
Genotype
Humans
Polymerase Chain Reaction
Promoter Regions, Genetic
Risperidone
Schizophrenia
Serotonin Plasma Membrane Transport Proteins*
Serotonin*
Triglycerides
Antipsychotic Agents
Blood Glucose
Cholesterol
Clozapine
DNA
Risperidone
Serotonin
Serotonin Plasma Membrane Transport Proteins