J Bone Metab.  2014 Aug;21(3):163-167. 10.11005/jbm.2014.21.3.163.

Factors and Mechanisms Involved in the Coupling from Bone Resorption to Formation: How Osteoclasts Talk to Osteoblasts

• Ikeda K
• Takeshita

• KMID: 2286286
• DOI: http://doi.org/10.11005/jbm.2014.21.3.163

Abstract

Bone remodeling is the fundamental means by which the quality as well as quantity of the skeleton is maintained throughout adult life. When bone remodeling goes awry, a metabolic bone disease such as osteoporosis ensues. Among multiple phases of the complex remodeling process, we focus in this review on factors and mechanisms that are involved in the coupling of bone formation to preceding resorption.

Keyword

Bone remodeling; Bone resorption; Osteoblasts; Osteoclasts

MeSH Terms

Adult
Bone Diseases, Metabolic
Bone Remodeling
Bone Resorption*
Humans
Osteoblasts*
Osteoclasts*
Osteogenesis
Osteoporosis
Skeleton

Figure

• 

  Fig. 1 Complement component 3a (C3a) and collagen triple helix repeat containing 1 (Cthrc1) in the communication between osteoclasts (OC) and osteoblasts (OB). Bone marrow macrophages (BMM) become committed preOC and then mature, multinucleated OC (mOC). C3a is derived from mOC and acts on bone marrow stromal cells (BMSC) to stimulation osteoblastogenesis. Cthrc1 is secreted from mature active OC (maOC) in the middle of bone resorption and stimulates OB differentiation as well as recruitment of BMSC or mesenchymal stem cells (MSC) to resorption lacunae.

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