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Factors and Mechanisms Involved in the Coupling from Bone Resorption to Formation: How Osteoclasts Talk to Osteoblasts

Ikeda K, Takeshita

Bone remodeling is the fundamental means by which the quality as well as quantity of the skeleton is maintained throughout adult life. When bone remodeling goes awry, a metabolic bone...
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Transcatheter Arterial Chemotherapy with Miriplatin for Hepatocellular Carcinoma Patients with Chronic Renal Failure: Report of Three Cases

Imai N, Ikeda K, Seko Y, Kawamura Y, Sezaki H, Hosaka T, Akuta N, Kobayashi , Saitoh S, Suzuki F, Suzuki Y, Arase Y, Kumada H

  • KMID: 2135078
  • Gut Liver.
  • 2013 Mar;7(2):246-251.
Miriplatin is a novel lipophilic platinum complex that was developed to treat hepatocellular carcinoma (HCC). Although HCC patients frequently have coexisting chronic renal failure, little prospective data are available regarding...
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Influences of Allocating HIV/AIDS Specialized Nurses on Clinical Outcomes in Japan

Nishigaki , Sugino Y, Seo J, Shimada M, Ikeda K, Kazuma K

  • KMID: 2168149
  • Asian Nurs Res.
  • 2011 Mar;5(1):11-18.
PURPOSE: This retrospective cohort study was conducted to demonstrate how allocation of nurses specialized in HIV care influences clinical outcomes of antiretroviral therapy (ART) for people living with HIV (PLWH). METHODS:...
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Preoperative flexion contracture is a predisposing factor for cartilage degeneration at the patellofemoral joint after open wedge high tibial osteotomy

Otsuki S, Ikeda K, Wakama H, Okuno N, Okamoto Y, Okayoshi T, Miyamoto Y, Neo M

Purpose: The purpose of the study was to determine the effect of cartilage degeneration at the patellofemoral joint on clinical outcomes after open wedge high tibial osteotomy and to investigate...
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Pilot Study for Considering Subthalamic Nucleus Anatomy during Stimulation Using Directional Leads

Asahi T, Ikeda K, Yamamoto J, Tsubono H, Sato S

OBJECTIVE: Directional leads are used for deep brain stimulation (DBS). Two of the four contacts of the leads are divided into three parts, enabling controlled stimulation in a circumferential direction....
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Effects of an Active Noise Control Technology Applied to Earphones on Preferred Listening Levels in Noisy Environments

Hoshina T, Fujiyama D, Koike T, Ikeda K

Background and Objectives: The harmful effects of frequent exposure to loud sounds through portable music players (PMPs) in combination with earphones have been suggested to result in a high prevalence...
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What Is the Most Effective Drug Delivery System for Cisplatin during the Treatment of Hepatic Tumors with Single-Session Transcatheter Chemotherapy? A Pilot Study

Kawamura Y, Ikeda K, Fukushima , Seko Y, Hara T, Sezaki H, Hosaka T, Akuta N, Kobayashi , Saitoh S, Suzuki F, Suzuki Y, Arase Y, Kumada H

  • KMID: 1806675
  • Gut Liver.
  • 2013 Sep;7(5):576-584.
BACKGROUND/AIMS: The aim of this study was to determine the pharmacodynamics of cisplatin following three different treatment procedures for intrahepatic arterial infusion therapy for hepatocellular carcinoma (HCC). METHODS: We divided 13...
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Connective Tissue Growth Factor Neutralization Aggravates the Psoriasis Skin Lesion: The Analysis of Psoriasis Model Mice and Patients

Hayakawa K, Ikeda K, Fujishiro , Yoshida Y, Hirai T, Tsushima H, Miyashita , Morimoto S, Suga Y, Takamori K, Ogawa H, Sekigawa I

BACKGROUND: Connective tissue growth factor (CTGF) is a multifunctional cellular protein and playing a role as a central mediator in tissue remodeling and fibrosis. The physiological function of CTGF in...
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Estrogen affects vascular tone differently according to vasoactive substances in ovariectomized Sprague-Dawley rat

Seo B, Ikeda K, Emoto N, Choi DJ, Hwang JY, Matsuo M, Kim EJ, Cheon IS

The favorable effects of estrogen on cardiovascular diseases can be explained by several mechanisms such as changes in serum lipid profiles and thrombogenecity. Estrogen also affects the vascular tone, but...
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Relationships between Genetic Variations of PNPLA3, TM6SF2 and Histological Features of Nonalcoholic Fatty Liver Disease in Japan

Akuta N, Kawamura Y, Arase Y, Suzuki F, Sezaki H, Hosaka T, Kobayashi , Kobayashi , Saitoh S, Suzuki Y, Ikeda K, Kumada H

BACKGROUND/AIMS: It is important to determine the noninvasive parameters of histological features in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the value of genetic...
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No Association between the Polymorphism rs6943555 in the AUTS2 Gene and Personality Traits in Japanese University Students

Narita S, Ikeda K, Nishizawa , Yoshihara , Numajiri M, Onozawa Y, Ohtani N, Iwahashi K

OBJECTIVE: The autism susceptibility candidate 2 (AUTS2) gene has been implicated in multiple neurological disorders. Several recent studies have revealed that the polymorphism rs6943555 in the AUTS2 gene is broadly...
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Noninvasive Assessment of Advanced Fibrosis Based on Hepatic Volume in Patients with Nonalcoholic Fatty Liver Disease

Hayashi T, Saitoh S, Fukuzawa K, Tsuji Y, Takahashi , Kawamura Y, Akuta N, Kobayashi , Ikeda K, Fujii T, Miyati T, Kumada H

BACKGROUND/AIMS: Noninvasive liver fibrosis evaluation was performed in patients with nonalcoholic fatty liver disease (NAFLD). We used a quantitative method based on the hepatic volume acquired from gadoxetate disodium-enhanced (Gd-EOB-DTPA-enhanced)...
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