Gut Liver.  2013 Mar;7(2):246-251.

Transcatheter Arterial Chemotherapy with Miriplatin for Hepatocellular Carcinoma Patients with Chronic Renal Failure: Report of Three Cases

• Imai N
• Ikeda K
• Seko Y
• Kawamura Y
• Sezaki H
• Hosaka T
• Akuta N
• Kobayashi
• Saitoh S
• Suzuki F
• Suzuki Y
• Arase Y
• Kumada H

Abstract

Miriplatin is a novel lipophilic platinum complex that was developed to treat hepatocellular carcinoma (HCC). Although HCC patients frequently have coexisting chronic renal failure, little prospective data are available regarding the clinical toxicity of chemotherapeutic agents used to treat HCC patients with chronic renal failure. In a phase II study, the plasma concentration of total platinum in patients who received miriplatin was very low, and no severe renal toxicity caused by miriplatin injection was reported. Here, we present three cases of HCC with stage 4 chronic renal failure who received transcatheter arterial chemotherapy with miriplatin. All cases were male, ages 72, 84, and 83 years, and had serum creatinine levels of 2.3, 1.6, and 1.9 mg/dL, respectively. Their estimated glomerular filtration rates were 21.9, 20.3, and 22.2 mL/min, respectively. All cases were treated for unresectable HCC with transcatheter arterial chemotherapy with miriplatin. No serious adverse events were observed, and serum creatinine levels did not elevate, even in the patient who experienced renal failure caused by cisplatin administration. These results might suggest that transcatheter arterial chemotherapy with miriplatin can be safely used in HCC patients with chronic renal failure.

Keyword

Miriplatin; Chronic renal failure; Hepatocellular carcinoma

MeSH Terms

Carcinoma, Hepatocellular
Cisplatin
Creatinine
Glomerular Filtration Rate
Humans
Kidney Failure, Chronic
Male
Organoplatinum Compounds
Plasma
Platinum
Renal Insufficiency
Cisplatin
Creatinine
Organoplatinum Compounds
Platinum