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Reference Intervals for Bone Turnover Markers in Korean Healthy Women

Cho DH, Chung JO, Chung MY, Cho JR, Chung DJ

BACKGROUND: Adequate suppression of bone turnover rate is important to decrease fracture risk without mineralization defect due to oversuppression. This study was performed to determine reference intervals (RIs) for 2...
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The effect of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion

Hwang S, Chung CJ, Choi YJ, Kim T, Kim KH

OBJECTIVE: The objective of this study was to evaluate the effects of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion. METHODS: Sixty male Sprague–Dawley rats were...
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Mechanical and Mechanosensing Properties of Tumor Affected Bone Cells Were Inhibited via PI3K/Akt Pathway

Lee T

BACKGROUND: Osteolytic metastasis is a common destructive form of metastasis, in which there is an increased bone resorption but impaired bone formation. It is hypothesized that the changed mechanical properties...
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Effects of Di(2-ethylhexyl)phthalate on Bone Metabolism in Ovariectomized Mice

Choi JI, Cho HH

BACKGROUND: The molecular pathways of how endocrine disruptors affect bone mineral density (BMD) and bone remodeling are still unclear. The purpose of this experimental study is to determine the effects...
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Alveolar restoration following rapid maxillary expansion with and without corticotomy: A microcomputed tomography study in sheep

Le MH, Noor Hayaty AK, Zaini ZM, Dom SM, Ibrahim N, Radzi ZB

OBJECTIVE: This study examined bone microstructure restoration after rapid maxillary expansion (RME) with and without corticotomy over multiple retention periods. METHODS: Eighteen male Dorper sheep were randomly distributed into three groups...
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Additive effects of eldecalcitol in poorly responding long-term bisphosphonate treatment for osteoporosis

Kamimura M, Ikegami S, Mukaiyama , Koiwai H, Nakamura Y, Taguchi A, Kato H

OBJECTIVES: We examined whether eldecalcitol (ELD) provided additive bone mineral density (BMD) and bone turnover marker gains in patients undergoing long-term bisphosphonate (BP) usage, especially in osteoporotic individuals exhibiting a...
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Diabetes and bone

Hygum K, Starup-Linde J, Langdahl B

Bone disease is a serious complication to diabetes. Patients with type 1 diabetes (T1D) and type 2 diabetes (T2D) suffer from an increased risk of fracture, most notably at the...
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Effect of Preoperative Bisphosphonate Treatment on Fracture Healing after Internal Fixation Treatment of Intertrochanteric Femoral Fractures

Lim EJ, Kim JT, Kim CH, Kim JW, Chang JS, Yoon PW

PURPOSE: There are concerns that administration of bisphosphonate (BP) can substantially suppress bone turnover, potentially interfering with fracture healing. We investigated the effects of preoperative BP administration before internal fixation...
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Effectiveness of monthly intravenous ibandronate injections in a real-world setting: Subgroup analysis of a postmarketing observational study

Takeuchi Y, Hashimoto , Kakihata H, Nishida Y, Kumagai M, Yamagiwa C

OBJECTIVES: The favorable safety and consistent effectiveness of monthly intravenous (IV) ibandronate injections was demonstrated in a prospective, postmarketing, observational study in Japanese patients with osteoporosis. Here, we present subgroup...
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Clinical Application of Bone Turnover Markers in Osteoporosis in Korea

Park SY, Ahn SH, Yoo JI, Chung YJ, Jeon YK, Yoon BH, Kim HY, Lee SH, Lee J, Hong S

Bone turnover markers (BTMs) have important role in the management of osteoporosis. Recently the clinical application of BTMs has achieved significant progress and measurement of BTMs give us better understanding...
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Is There a Role of Pharmacological Treatments in the Prevention or Treatment of Osteonecrosis of the Femoral Head?: A Systematic Review

Lee YJ, Cui Q, Koo KH

BACKGROUND: Various pharmacological treatments have been suggested to treat osteonecrosis of the femoral head. However, their practicability remains a controversial issue. METHODS: We systemically reviewed articles published during last 20 years...
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The Function of the Vitamin D Receptor and a Possible Role of Enhancer RNA in Epigenomic Regulation of Target Genes: Implications for Bone Metabolism

Sawatsubashi S, Nishimura , Mori J, Kouzmenko , Kato S

Vitamin D (VD) is essential for bone health, and VD or its analogues are widely used in clinics to ameliorate bone loss. The targets and mode of VD anti-osteoporotic actions...
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Bone healing dynamics associated with 3 implants with different surfaces: histologic and histomorphometric analyses in dogs

Lee J, Yoo JM, Amara HB, Lee YM, Lim YJ, Kim H, Koo KT

PURPOSE: This study evaluated differences in bone healing and remodeling among 3 implants with different surfaces: sandblasting and large-grit acid etching (SLA; IS-III Active®), SLA with hydroxyapatite nanocoating (IS-III Bioactive®),...
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Serum 25-hydroxyvitamin D concentrations in Japanese postmenopausal women with osteoporotic fractures

Yamanaka Y, Menuki K, Zenke Y, Ikeda S, Hatakeyama E, Kawano K, Nishida S, Tanaka H, Yumisashi , Sakai A

OBJECTIVES: To assess the vitamin D status in postmenopausal women with osteoporotic fractures, determine its concentration by fracture site at the clinical setting, and compare the proportion of vitamin D...
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Serum Procollagen Type I N-Terminal Propeptide and Osteocalcin Levels in Korean Children and Adolescents

Choi JS, Park I, Lee SJ, Ju HJ, Lee H, Kim J

PURPOSE: Bone markers can be useful for the diagnosis and treatment of skeletal diseases in children and adolescents. Owing to high skeletal growth velocity and rapid bone turnover, children and...
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Use of Bone Turnover Markers in Clinical Practice for the Management of Osteoporosis in Korea: From the Survey on the Prescription Pattern of Bone Turnover Markers

Ahn SH, Park SY, Yoo JI, Chung YJ, Jeon YK, Yoon BH, Kim HY, Lee SH, Lee J, Hong S

BACKGROUND: There has been interest in the clinical potential of bone turnover markers (BTMs) as tools both for assessing fracture risk and for monitoring treatment. However, the practical use of...
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Bone Marrow Foot Oedema in Adolescents: The Role of Vitamin D

Pieropan S, Antoniazzi F, Tadiotto E, Caldonazzi F, Maschio M, Aiello G, Melotti G, Cavarzere , Piacentini G

BACKGROUND: Bone marrow oedema (BMO) in children/adolescents is a rare clinical condition without an etiologic cause. It is associated with typical increased signal intensity on T2-weighted magnetic resonance images (MRI)...
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Position Statement on the Use of Bone Turnover Markers for Osteoporosis Treatment

Park SY, Ahn SH, Yoo JI, Chung YJ, Jeon YK, Yoon BH, Kim HY, Lee SH, Lee J, Hong S

Current evidences continue to support the clinical application of bone turnover markers (BTMs) in the management of postmenopausal osteoporosis. The limitations of bone mineral density measured by dual energy X-ray...
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Pharmacological treatment of osteoporosis

Chun S

Osteoporosis is a skeletal disorder characterized by compromised bone strength resulting in a predisposition to fracture. Osteoporosis-related fractures can lead to pain, disability, and increased healthcare costs. This study aimed...
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Skeletal Fragility in Type 2 Diabetes Mellitus

Starup-Linde J, Hygum K, Langdahl B

Type 2 diabetes (T2D) is associated with an increased risk of fracture, which has been reported in several epidemiological studies. However, bone mineral density in T2D is increased and underestimates...
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