J Korean Diabetes.  2013 Dec;14(4):174-177. 10.4093/jkd.2013.14.4.174.

Bone and Energy Metabolism

• Lee S
• Rhee Y

• KMID: 2173930
• DOI: http://doi.org/10.4093/jkd.2013.14.4.174

Abstract

Bone remodeling requires a large amount of energy, and is regulated by various hormones. Leptin, produced by adipocytes, is a well-known regulator of energy balance and is also involved in controlling bone mass through interaction with the central nervous system. Serotonin, downstream of leptin, is also emerging as a candidate for controlling energy balance and bone metabolism. Currently, bone is also considered to be an endocrine regulator of energy metabolism. Osteocalcin, secreted from osteoblasts, is known to be a key regulator of glucose and fat metabolism. In this review, we describe a novel concept that asserts that there exists a biological link between bone and energy metabolism, and we summarize what is currently known about the relationship between bone and energy metabolism.

Keyword

Bone; Energy metabolism; Leptin; Serotonin; Neurotransmitter agents; Osteocalcin

MeSH Terms

Adipocytes
Bone Remodeling
Central Nervous System
Energy Metabolism*
Glucose
Leptin
Metabolism
Neurotransmitter Agents
Osteoblasts
Osteocalcin
Serotonin
Glucose
Leptin
Neurotransmitter Agents
Osteocalcin
Serotonin

Reference

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