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The Association of Coronary Artery Calcium Score and Osteoporosis in Postmenopausal Women: A Cross-Sectional Study

Asadi M, Razi F, Fahimfar N, Shirani S, Behzad G, Salari P

Background: The association between osteoporosis, a common metabolic bone disorder, and atherosclerosis has been reported in different studies. In this study, we aimed to investigate the association between the coronary...
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Effect of Lactobacillus Fermentum as a Probiotic Agent on Bone Health in Postmenopausal Women

Han HS, Kim JG, Choi YH, Lee KM, Kwon TH, Kim SH

Background: Probiotics are live microorganisms that confer health benefits on the host. Many animal studies have shown that among the probiotics, lactobacilli exert favorable effects on bone metabolism. Herein, we...
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Changes in the Serum Levels of Parathyroid Hormone and Bone Metabolites in Two Serial Samples with Different Vitamin D Status

Park PW, Park IK

Background: Vitamin D increases serum calcium levels by promoting calcium absorption in intestines. Vitamin D deficiency raises the serum levels of parathyroid hormone (PTH) and bone metabolites. Generally, vitamin D...
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Effect of Intermittent Fasting on Glucose Homeostasis and Bone Remodeling in Glucocorticoid-Induced Osteoporosis Rat Model

Alrowaili MG, Hussein AM, Eid EA, Serria MS, Abdellatif H, Sakr HF

Background: The present study examined the effect of intermittent fasting (IF) on bone mineral content (BMC) and bone mineral density (BMD) and the markers of bone remodeling in a glucocorticoid-induced...
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Association between Serum Osteocalcin Levels and Metabolic Syndrome according to the Menopausal Status of Korean Women

Moon JS, Jin MH, Koh HM

Background: Osteocalcin is known to regulate energy metabolism. Recently, metabolic syndrome (MetS) has been found to be associated with reduced levels of osteocalcin in men, as well as in postmenopausal...
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Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury

Thakkar P, Prakash NB, Tharion G, Shetty S, Paul TV, Bondu J, Yadav B

Study Design: Prospective observational study. Purpose: To evaluate bone turnover markers (BTMs) in individuals with acute spinal cord injury (SCI) and to compare the results with those of healthy controls and...
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Reference Intervals for Bone Turnover Markers in Korean Healthy Women

Cho DH, Chung JO, Chung MY, Cho JR, Chung DJ

BACKGROUND: Adequate suppression of bone turnover rate is important to decrease fracture risk without mineralization defect due to oversuppression. This study was performed to determine reference intervals (RIs) for 2...
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An overview of the endocrine functions of osteocalcin

Baek K

Osteocalcin is the most abundant non-collagenous protein produced in bone. It has traditionally been regarded as a marker of bone turnover and is thought to act in the bone matrix...
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Serum Procollagen Type I N-Terminal Propeptide and Osteocalcin Levels in Korean Children and Adolescents

Choi JS, Park I, Lee SJ, Ju HJ, Lee H, Kim J

PURPOSE: Bone markers can be useful for the diagnosis and treatment of skeletal diseases in children and adolescents. Owing to high skeletal growth velocity and rapid bone turnover, children and...
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Early reduced bone formation following burn injury in rats is not inversely related to marrow adiposity

El Ayadi A, Helderman , Finnerty C, Herndon DN, Rosen CJ, Klein GL

OBJECTIVES: The objective of the study was to determine whether postburn reduction of bone formation occurred earlier than 2–3 weeks after burn injury and whether that reduction was inversely related...
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Serum osteocalcin levels in overweight children

Oh SB, Lee WY, Nam HK, Rhie YJ, Lee KH

PURPOSE: Bone plays a role in glucose metabolism through the release of uncarboxylated osteocalcin into the systemic circulation. The identified novel roles for osteocalcin include increasing insulin secretion and sensitivity,...
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Antiosteoporotic activity of Salvadora persica sticks extract in an estrogen deficient model of osteoporosis

Fouda AM, Youssef AR

OBJECTIVES: The effect of Salvadora persica sticks on prevention of tooth decay is well established, but the effect of S. persica stick extract (SPE) on the prevention/treatment of osteoporosis has...
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Association of Serum Osteocalcin with Metabolic Syndrome in Korean Adult Women

Kang JH

BACKGROUND: Serum osteocalcin level has been widely used as a bone turnover marker in clinical setting. In this study, we analyzed the relationship between serum osteocalcin concentration and metabolic syndrome...
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Coronary Artery Calcium Score and Bone Metabolism: A Pilot Study in Postmenopausal Women

Salari P, Keshtkar A, Shirani S, Mounesan L

BACKGROUND: Since 1991 many studies evaluated the link between cardiovascular diseases and osteoporosis, two age-related conditions, but the main common pathologic pathway has not been determined yet. The histological similarity...
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Assessment of the Role of Noni (Morinda citrifolia) Juice for Inducing Osteoblast Differentiation in Isolated Rat Bone Marrow Derived Mesenchymal Stem Cells

Hussain S, Tamizhselvi R, George L, Manickam V

BACKGROUND AND OBJECTIVES: Morinda citrifolia (Noni), an important traditional medicinal plant still used in patients with bone fractures or dislocation to promote connective tissue repair and to reduce inflammation. However,...
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Association of Serum Osteocalcin with Insulin Resistance and Coronary Atherosclerosis

Kang JH

BACKGROUND: To determine the associations between serum osteocalcin level and insulin resistance, coronary atherosclerosis by using dual-source coronary computed tomography angiography. METHODS: A total of 98 subjects (24 men and 74...
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Osteocalcin Expression and Mineralization in Developing Tooth of Xenopus laevis

Park JH, Kwon KT, Park BK, Lee YH

Osteocalcin (OC) is the most abundant noncollagenous protein of extracellular matrix in the bone. In an OC deficient mouse, bone formation rates are increased in cancellous and cortical bones. OC...
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Serum Sclerostin in Hepatitis C Virus Infected Patients

Gonzalez-Reimers E, Lopez-Prieto J, Pelazas-Gonzalez R, Aleman-Valls MR, Jose de la Vega-Prieto M, Jorge-Ripper C, Duran-Castellon MC, Santolaria-Fernandez F

  • KMID: 2391955
  • J Bone Metab.
  • 2014 Feb;21(1):69-75.
BACKGROUND: Sclerostin inhibits osteoblast functions, differentiations, and survival rates. As an endogenous inhibitor of the Wnt/beta-catenin pathway, the sclerostin should be related to decreased bone masses, although several studies indicate...
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Bone and Energy Metabolism

Lee S, Rhee Y

Bone remodeling requires a large amount of energy, and is regulated by various hormones. Leptin, produced by adipocytes, is a well-known regulator of energy balance and is also involved in...
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Ascorbic acid insufficiency induces the severe defect on bone formation via the down-regulation of osteocalcin production

Kim W, Bae S, Kim H, Kim Y, Choi J, Lim SY, Lee HJ, Lee J, Choi J, Jang M, Lee KE, Chung SG, Hwang YI, Kang JS, Lee WJ

The L-gulono-gamma-lactone oxidase gene (Gulo) encodes an essential enzyme in the synthesis of ascorbic acid from glucose. On the basis of previous findings of bone abnormalities in Gulo-/- mice under...
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