J Bone Metab.  2015 Feb;22(1):1-8. 10.11005/jbm.2015.22.1.1.

Pathogenesis, Management and Prevention of Atypical Femoral Fractures

Affiliations
  • 1Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Korea. gunil@duih.org

Abstract

Much attention has been paid to the relationship between atypical femoral fractures (AFF) and use of bisphosphonates (BPs). While a significant cause-effect relationship was not established in earlier studies, more recent data shows a growing relationship between AFF and BPs use. The definition of an 'AFF' has also undergone significant changes. This review briefly summarizes the definition, pathogenesis, and management of AFF.

Keyword

Bone remodeling; Diphosphonates; Femoral fractures

MeSH Terms

Bone Remodeling
Diphosphonates
Femoral Fractures*
Diphosphonates

Figure

  • Fig. 1 Sixty-eight-year-old woman with left hip pain. In initial radiograph (left side), there is cortical thickening of lateral cortex of left femur subtrochanter area. One day after (right side), occurred left femoral fracture with no trauma. (Provide by Seung-Jae Lim, MD, Samsung Medical Center).

  • Fig. 2 Action of bisphosphonates in bone healing process.

  • Fig. 3 The strategy of bisphosphonate therapy. BP, bisphosphonate; BMD, bone mineral density.

  • Fig. 4 Management of atypical femoral fracture.


Cited by  4 articles

Atypical Femoral Fractures: What Do We Know about Them?
Beom Seok Lee, Young-Kyun Lee, Heejae Won, Hyungkook Kim, Kyung-Hoi Koo
J Korean Fract Soc. 2018;31(4):159-164.    doi: 10.12671/jkfs.2018.31.4.159.

Atypical Femoral Fracture: 2015 Position Statement of the Korean Society for Bone and Mineral Research
Kyu Hyun Yang, Byung Woo Min, Yong-Chan Ha
J Bone Metab. 2015;22(3):87-91.    doi: 10.11005/jbm.2015.22.3.87.

Localization of Atypical Femoral Fracture on Straight and Bowed Femurs
Young-Chang Park, Soon-Phil Yoon, Kyu Hyun Yang
J Bone Metab. 2019;26(2):123-131.    doi: 10.11005/jbm.2019.26.2.123.

Incidence Rate of Atypical Femoral Fracture after Bisphosphonates Treatment in Korea
Young-Kyun Lee, Soyeon Ahn, Kyoung Min Kim, Chang Suk Suh, Kyung-Hoi Koo
J Korean Med Sci. 2018;33(5):.    doi: 10.3346/jkms.2018.33.e38.


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