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Multidisciplinary Consensus on the Prevention and Treatment of Osteoporosis and Fragility Fractures in Patients with Prostate Cancer Receiving Androgen-Deprivation Therapy

Casado E, Borque-Fernando A, Caamaño M, Graña J, Muñoz-Rodríguez J, Morote J

Patients with prostate cancer (PCa) on androgen-deprivation therapy (ADT) are at high risk of osteoporosis and fragility fractures. We aimed to provide some practical insights into the delivery of optimal...
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Long-Term Treatment of Postmenopausal Osteoporosis

Brown JP

Osteoporosis is an incurable chronic condition, like heart disease, diabetes, or hypertension. A large gap currently exists in the primary prevention of fractures, and studies show that an estimated 80%...
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Review and Update of the Risk Factors and Prevention of Antiresorptive-Related Osteonecrosis of the Jaw

Kim HY

Antiresorptive-related osteonecrosis of the jaw (ARONJ) is a rare but serious adverse event of bisphosphonate or denosumab administration; it is associated with severe pain and a deteriorated quality of life....
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Use of Bisphosphonates, Calcium and Vitamin D for Bone Demineralization in Patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome: A Systematic Review and Meta-Analysis of Clinical Trials

Rocha VMd, Faria MBB, Júnior FdAdR, Lima COGX, Fiorelli RKA, Cassiano KM

Background: The present study performed a systematic review and meta-analysis of clinical trials using bisphosphonates for bone demineralization in human immunodeficiency virus (HIV) patients. Methods: A comprehensive literature search was...
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The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats

Yadegari A, Aminzadeh A, Seyyedkhamesi S, Aminian M

Objectives: Melatonin induces human stem cells, converts pre-osteoblasts to mature osteoblasts, and reduces the duration of this transition. However, melatonin itself prevents activation of osteoclasts. Here, we evaluate the role...
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Is Full-Length Intramedullary Nail Necessary for Atypical Subtrochanteric Femoral Fracture Associated with Bisphosphonate?

Kim Kk, Ryu Sk, Lee SW, Cha Hj

Background: American Society for Bone and Mineral Research recommend the use of intramedullary reconstruction of full length-nail for atypical subtrochanteric femoral fracture (ASFF). However, there is no study on the...
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Paget's Disease of Bone Affecting Peripheral Limb: Difficulties in Diagnosis: A Case Report

Lee JK, Kang YK, Wang PW, Hong SM

In terms of management of Paget's disease of bone (PDB), early diagnosis and proper management achieving remission is essential with lifelong specialist follow-up. We present the case of a 40-year-old...
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Effect of Osteoporosis Medication on Fracture Healing: An Evidence Based Review

Shin YH, Shin WC, Kim JW

A systematic search was conducted and relevant studies that evaluated the influence of osteoporosis medications (bisphosphonates [BPs], denosumab, selective estrogen receptor modulators [SERMs], recombinant human parathyroid hormone teriparatide [TPTD], and...
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Single Dose Therapy of Zoledronic Acid for the Treatment of Transient Osteoporosis of Hip

Agarwala S, Vijayvargiya M

OBJECTIVE: To shorten the natural course of transient osteoporosis of hip (TOH), which is a self-limiting idiopathic condition and requires 6–12 months for the resolution of symptoms, various therapies including...
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Is There a Role of Pharmacological Treatments in the Prevention or Treatment of Osteonecrosis of the Femoral Head?: A Systematic Review

Lee YJ, Cui Q, Koo KH

BACKGROUND: Various pharmacological treatments have been suggested to treat osteonecrosis of the femoral head. However, their practicability remains a controversial issue. METHODS: We systemically reviewed articles published during last 20 years...
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Korean Guideline for the Prevention and Treatment of Glucocorticoid-induced Osteoporosis

Park SY, Gong HS, Kim KM, Kim D, Kim H, Jeon CH, Ju JH, Lee SS, Park DA, Sung YK, Kim SW

OBJECTIVE: To develop guidelines and recommendations to prevent and treat glucocorticoid-induced osteoporosis (GIOP) in Korea. METHODS: The Korean Society for Bone and Mineral Research and the Korean College of Rheumatology developed...
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Bisphosphonate's and Intermittent Parathyroid Hormone's Effect on Human Spinal Fusion: A Systematic Review of the Literature

Stone MA, Jakoi AM, Iorio JA, Pham MH, Patel NN, Hsieh PC, Liu JC, Acosta FL, Hah R, Wang JC

There has been a conscious effort to address osteoporosis in the aging population. As bisphosphonate and intermittent parathyroid hormone (PTH) therapy become more widely prescribed to treat osteoporosis, it is...
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The Efficacy of Bisphosphonates for Prevention of Osteoporotic Fracture: An Update Meta-analysis

Byun JH, Jang S, Lee S, Park S, Yoon HK, Yoon BH, Ha YC

BACKGROUND: The efficacy of bisphosphonates for osteoporotic fracture has been consistently reported in recent randomized controlled trials (RCTs) enrolling hundreds of patients. The objective of this study was to update...
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Which Bisphosphonate? It's the Compliance!: Decision Analysis

Lee YJ, Park CH, Lee YK, Ha YC, Koo KH

BACKGROUND: The best options of several bisphosphonates for prevention of osteoporotic fractures in postmenopausal women remain controversial. We determined which bisphosphonate provides better efficacy in prevention of osteoporotic fractures using...
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Pathogenesis, Management and Prevention of Atypical Femoral Fractures

Im GI, Jeong SH

Much attention has been paid to the relationship between atypical femoral fractures (AFF) and use of bisphosphonates (BPs). While a significant cause-effect relationship was not established in earlier studies, more...
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Position Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South Korea

Lee SH, Gong HS, Kim TH, Park SY, Shin JH, Cho SW, Byun DW

Bisphosphonates have been widely used in the treatment of osteoporosis with robust data from many placebo-controlled trials demonstrating its efficacy in fracture risk reduction over 3 to 5 years of...
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The Frequency of and Risk Factors for the Use of Bisphosphonates in the Adjuvant Setting of Primary Breast Cancer in Germany

Fick EM, Katalinic , Waldmann A

PURPOSE: The aim of this cross-sectional health care study (use of bisphosphonates in primary tumors of the mammae, EBisMa) is to determine how often bisphosphonate medication is used in patients...
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Intravenous Zoledronate for a Patient with Paget's Disease

Kim KC

Paget's disease (PD) of bone is characterized by increase of bone resorption by atypical osteoclasts, followed by rapid new bone formation resulting in a disorganized mosaic bone. Although the pathophysiology...
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Risk Factors of New Adjacent Compression Fracture after Percutaneous Vertebroplasty: Effectiveness of Bisphosphonate in Osteoporotic or Osteopenic Elderly Patients

Seo DH, Oh SH, Yoon KW, Ko JH, Kim YJ, Lee JY

OBJECTIVE: The purpose of this study is to investigate the incidence of new compression and to analyze factors that influence the fractures in adjacent levels after percutaneous vertebroplasty (PVP). METHODS: This...
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Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation

Moon MH, Jeong JK, Seo JS, Seol JW, Lee YJ, Xue M, Jackson CJ, Park SY

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, is one of the most promising candidates for cancer therapeutics. However, many osteosarcomas are resistant...
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