Korean J Physiol Pharmacol.
2002 Oct;6(5):235-240.
The Preventive Effects of Bcl-2 and Bcl-xL on Lovastatin-induced Apoptosis of C6 Glial Cells
- Affiliations
-
- 1Department of Pharmacology, Yonsei University Wonju College of Medicine, Gangwon-do, Korea. jwchoiphar@wonju.yonsei.ac.kr
- 2Institute of Basic Medical Science, Yonsei University Wonju College of Medicine, Gangwon-do, Korea.
- 3The Institute of Functional Biomaterials and Biotechnology, Yonsei University, Gangwon-do, Korea.
- 4Department of Biology, Yonsei University College of Science, Seoul, Korea.
Abstract
- It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25microM)- induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation was unaffected by Bcl-2 or Bcl-xL overexpression. These results suggest that Bcl-2 and Bcl-xL can prevent lovastatin-induced apoptosis in C6 glial cells, though the inhibition of proliferation remains unaffected by these proteins.
Keyword
- Lovastatin; Apoptosis; C6; Bcl-2; Bcl-xL
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Fluoxetine Up-Regulates Bcl-xL Expression in Rat C6 Glioma Cells
- Function of bcl-X proteins in Nitric Oxide-induced Apoptosis in RAW 264.7 Macrophages
- The Apoptosis and Expression of Bcl-2, Bcl-xS, Bax Proteins in Fetal Brain after Treating Pregnant Mice with Endotoxin
- Apoptosis of Prostate Cancer by Inhibition of Bcl-xL Expression
- Increased Viability by Over-Expression of Bcl-XL in a Human Neural Progenitor Cell Line
