- The Protective Effect of Green Tea Extract on Alpha-amanitin Induced Hepatotoxicity
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An SH, Sun KH, Hong R, Lee BR, Park Y
- KMID: 2470188
- J Korean Soc Clin Toxicol.
- 2019 Dec;17(2):58-65.
- doi: 10.22537/jksct.2019.17.2.58
PURPOSE: Alpha-amanitin induces potent oxidative stress and apoptosis, and may play a significant role in the pathogenesis of hepatotoxicity. This study examined the mechanisms of α-amanitin-induced apoptosis in vitro, and... -
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- Specific tail swelling pattern in hypo-osmotic solution as a predictor of DNA fragmentation status in human spermatozoa
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Kim SW, Nho EJ, Lee JY, Jee BC
- KMID: 2469590
- Clin Exp Reprod Med.
- 2019 Dec;46(4):147-151.
- doi: 10.5653/cerm.2019.00458
OBJECTIVE: The aim of this study was to investigate DNA fragmentation status in human spermatozoa according to specific tail swelling patterns determined via hypo-osmotic swelling test (HOST). METHODS: Frozen semen samples... -
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- Potential biomarkers and antagonists for fluoranthene-induced cellular toxicity of bone marrow derived mesenchymal stem cells
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Hoque MM, Lee YE, Kim HR, Shin MG
- KMID: 2466590
- Blood Res.
- 2019 Dec;54(4):253-261.
- doi: 10.5045/br.2019.54.4.253
BACKGROUND: Fluoranthene (FR) is a common environmental pollutant that exists in a complex mixture with other polycyclic aromatic hydrocarbons (PAHs). We identified biomarkers for monitoring FR exposure and investigated the... -
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- Anti-cancer Activity of Paclitaxel, Lenvatinib and Radiation Combination Therapy on Anaplastic Thyroid Cancer in Vitro and in Vivo
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Jun S, Kim SY, Kim SM, Park KC, Kim HJ, Chang HJ, Lee YS, Chang HS, Park CS
- KMID: 2469230
- Korean J Head Neck Oncol.
- 2019 Nov;35(2):19-25.
- doi: 10.21593/kjhno/2019.35.2.19
BACKGROUND/OBJECTIVES: Although anaplastic thyroid carcinoma (ATC) is rare, it is one of the deadliest forms of thyroid cancer. The fatality rate for ATC is high, and the survival rate at... -
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- Improvement of Human Sperm Vacuolization and DNA Fragmentation Co-Cultured with Adipose-Derived Mesenchymal Stem Cell Secretome: In Vitro Effect
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Bader R, Ibrahim JN, Mourad A, Moussa M, Azoury J, Azoury J, Alaaeddine N
- KMID: 2465879
- Int J Stem Cells.
- 2019 Nov;12(3):388-399.
- doi: 10.15283/ijsc19047
BACKGROUND AND OBJECTIVES: Oxidative stress (OS) is known to be an important factor of male infertility. Adipose-derived mesenchymal stem cells (AD-MSCs) are known to have immune-modulatory and anti-oxidant effects through... -
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- ICSI using fresh and frozen PESA-TESA spermatozoa to examine assisted reproductive outcome retrospectively
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Javed A, Ramaiah MK, Talkad MS
- KMID: 2462121
- Obstet Gynecol Sci.
- 2019 Nov;62(6):429-437.
- doi: 10.5468/ogs.2019.62.6.429
OBJECTIVE: The male reproductive system generates, accumulates, and transports the sperm. In this study, 2 methods of surgically retrieving sperm, namely, testicular sperm aspiration (TESA) and percutaneous epididymal sperm aspiration... -
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- Long Non-Coding RNA LINC00525 Promotes the Stemness and Chemoresistance of Colorectal Cancer by Targeting miR-507/ELK3 Axis
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Wang S, Li J, Yang X
- KMID: 2465904
- Int J Stem Cells.
- 2019 Jul;12(2):347-359.
- doi: 10.15283/ijsc19041
BACKGROUND AND OBJECTIVES: This study aims to explore the effects of a long non-coding RNA, LINC00525, on colorectal cancer (CRC) and its underlying molecular mechanisms. METHODS: The qPCR, MTT, colony formation,... -
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- Dietary Antioxidant Intake in Relation to Semen Quality Parameters in Infertile Men: a Cross-Sectional Study
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Rahimlou M, Sohaei S, Nasr-Esfahani M, Nouri M
- KMID: 2454080
- Clin Nutr Res.
- 2019 Jul;8(3):229-237.
- doi: 10.7762/cnr.2019.8.3.229
The objective of this study was to assess the association between dietary antioxidant intake and semen quality parameters in infertile men. In this cross-sectional study, dietary antioxidant intake was evaluated... -
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- Does conventional freezing affect sperm DNA fragmentation?
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Le MT, Nguyen TT, Nguyen TT, Nguyen TV, Nguyen TA, Nguyen QH, Cao TN
- KMID: 2452645
- Clin Exp Reprod Med.
- 2019 Jun;46(2):67-75.
- doi: 10.5653/cerm.2019.46.2.67
OBJECTIVE: Sperm cryopreservation has been widely used in assisted reproductive technology, as it offers great potential for the treatment of some types of male infertility. However, cryopreservation may result in... -
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- Induction of Melanoma Cell-Selective Apoptosis Using Anti-HER2 Antibody-Conjugated Gold Nanoparticles
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Jeon HJ, Choi BB, Park KH, Hwang DS, Kim UK, Kim GC
- KMID: 2446955
- Yonsei Med J.
- 2019 Jun;60(6):509-516.
- doi: 10.3349/ymj.2019.60.6.509
PURPOSE: This study was conducted to verify the induction and mechanism of selective apoptosis in G361 melanoma cells using anti-HER2 antibody-conjugated gold nanoparticles (GNP-HER2). MATERIALS AND METHODS: Following GNP-HER2 treatment of... -
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- Effect of Sperm DNA Fragmentation on Embryo Quality in Normal Responder Women in In Vitro Fertilization and Intracytoplasmic Sperm Injection
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Kim SM, Kim SK, Jee BC, Kim SH
- KMID: 2443250
- Yonsei Med J.
- 2019 May;60(5):461-466.
- doi: 10.3349/ymj.2019.60.5.461
PURPOSE: To investigate the associations between sperm DNA fragmentation (SDF) and embryo formation rate in normal responder women to in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). MATERIALS AND METHODS: Fifty-three consecutive, fresh... -
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- Traditional Chinese Medicine as a Remedy for Male Infertility: A Review
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Zhou SH, Deng YF, Weng ZW, Weng HW, Liu ZD
- KMID: 2443233
- World J Mens Health.
- 2019 May;37(2):175-185.
- doi: 10.5534/wjmh.180069
Male infertility (MI) is a complex multifactorial disease, and idiopathic infertility accounts for 30% of cases of MI. At present, the evidence for the effectiveness of empirical drugs is limited,... -
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- Effects of paternal age on human embryo development in in vitro fertilization with preimplantation genetic screening
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Kim MK, Park JK, Jeon Y, Seok SH, Chang EM, Lee WS
- KMID: 2469603
- Clin Exp Reprod Med.
- 2019 Mar;46(1):22-29.
- doi: 10.5653/cerm.2019.46.1.22
OBJECTIVE: As paternal age increases, the quality of sperm decreases due to increased DNA fragmentation and aneuploidy. Higher levels of structural chromosomal aberrations in the gametes ultimately decrease both the... -
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- Evaluation of sperm DNA fragmentation using multiple methods: a comparison of their predictive power for male infertility
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Javed A, Talkad MS, Ramaiah MK
- KMID: 2469602
- Clin Exp Reprod Med.
- 2019 Mar;46(1):14-21.
- doi: 10.5653/cerm.2019.46.1.14
OBJECTIVE: The usual seminal profile has been customarily used for diagnosing male infertility based on an examination of semen samples. However, sperm DNA fragmentation has also been causally linked to... -
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- Evaluation of normal morphology, DNA fragmentation, and hyaluronic acid binding ability of human spermatozoa after using four different commercial media for density gradient centrifugation
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Lee D, Jee BC
- KMID: 2469601
- Clin Exp Reprod Med.
- 2019 Mar;46(1):8-13.
- doi: 10.5653/cerm.2019.46.1.8
OBJECTIVE: Density gradient centrifugation (DGC) is frequently used to isolate high-motility fractions of spermatozoa. We compared the efficacy of four DGC media in terms of the percentage of morphologically normal... -
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- Antioxidant activity of ethanol extract of Lycium barbarum's leaf with removal of chlorophyll
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Kim JE, Bae SM, Nam YR, Bae EY, Ly SY
- KMID: 2466680
- J Nutr Health.
- 2019 Feb;52(1):26-35.
- doi: 10.4163/jnh.2019.52.1.26
PURPOSE: The aim of this study was to estimate the antioxidant activities of 50%, 70%, and 100% ethanol extracts of Lycium barbarum leaf and chlorophyll removal extract. METHODS: The antioxidant activities... -
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- Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways
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Han X, Kang KA, Piao MJ, Zhen AX, Hyun YJ, Kim HM, Ryu YS, Hyun JW
- KMID: 2432065
- Biomol Ther.
- 2019 Jan;27(1):41-47.
- doi: 10.4062/biomolther.2018.047
The apoptotic effects of shikonin (5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione) on the human colon cancer cell line SNU-407 were investigated in this study. Shikonin showed dose-dependent cytotoxic activity against SNU-407 cells, with an estimated... -
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- What should be done for men with sperm DNA fragmentation?
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Kim GY
- KMID: 2419525
- Clin Exp Reprod Med.
- 2018 Sep;45(3):101-109.
- doi: 10.5653/cerm.2018.45.3.101
In an age when a small quantity of sperm can lead to pregnancy through in vitro fertilization or intracytoplasmic sperm injection, selecting healthy sperm is important. Sperm DNA fragmentation (SDF)... -
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- Abnormal Human Sperm Parameters Contribute to Sperm DNA Fragmentation in Men with Varicocele
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Park YS, Lee SH, Choi HW, Lee HS, Lee JS, Seo JT
- KMID: 2419324
- World J Mens Health.
- 2018 Sep;36(3):239-247.
- doi: 10.5534/wjmh.180014
PURPOSE: This study was performed to evaluate and compare threshold sperm parameters and sperm DNA fragmentation index (DFI), and further analyzed whether sperm DFI could be predicted from sperm parameters... -
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- Anti-Proliferative Activities of Vasicinone on Lung Carcinoma Cells Mediated via Activation of Both Mitochondria-Dependent and Independent Pathways
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Dey T, Dutta P, Manna P, Kalita J, Boruah HP, Buragohain AK, Unni B
- KMID: 2420392
- Biomol Ther.
- 2018 Jul;26(4):409-416.
- doi: 10.4062/biomolther.2017.097
Vasicinone, a quinazoline alkaloid from Adhatoda vasica Nees. is well known for its bronchodilator activity. However its antiproliferative activities is yet to be elucidated. Here-in we investigated the anti-proliferative effect... -
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