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Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells

Na YJ, Yu ES, Kim DS, Lee DH, Oh SC, Choi CW

Background/Aims: Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years. In addition, a considerable number of...
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Long Noncoding RNA HEIH Promotes Colorectal Cancer Tumorigenesis via Counteracting miR-939-Mediated Transcriptional Repression of Bcl-xL

Cui C, Zhai D, Cai L, Duan Q, Xie L, Yu J

PURPOSE: Studies have found that long noncoding RNA HEIH (lncRNA-HEIH) is upregulated and facilitates hepatocellular carcinoma tumor growth. However, its clinical significances, roles, and action mechanism in colorectal cancer (CRC)...
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Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells

Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH

Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition...
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Fluoxetine Up-Regulates Bcl-xL Expression in Rat C6 Glioma Cells

Choi MR, Oh DH, Kim SH, Yang BH, Lee JS, Choi J, Jeon HS, Chai YG, Park YC

  • KMID: 2316048
  • Psychiatry Investig.
  • 2011 Jun;8(2):161-168.
OBJECTIVE: To analyze both differentially expressed genes and the Bcl-xL protein expression after acute and chronic treatment with fluoxetine in rat C6 glioma cells. METHODS: C6 glioma cells were cultured for...
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Expression of Cyclin D1 and Bcl-xL in Basal Cell Carcinoma and Squamous Cell Carcinoma

Kwon JI, Kim SP, Lee KS, Cho JW

  • KMID: 2088180
  • Korean J Dermatol.
  • 2011 Mar;49(3):234-241.
BACKGROUND: Cyclin D1 has a key function in cell proliferation. Bcl-xL has anti-apoptotic effects that can protect against cell death. However, it is still largely unknown whether these proteins play...
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Induction of the Intrinsic Apoptotic Pathway by 3-Deazaadenosine Is Mediated by BAX Activation in HL-60 Cells

Lee SY, Ko KW, Kang WK, Choe YJ, Kim YH, Kim IK, Kim J, Kim HS

3-Deazaadenosine (DZA), a potent inhibitor of S-adenosylhomocysteine hydrolase, was previously proposed to induce intrinsic apoptosis in human leukemic cells. In the present study, we analyzed the mechanism underlying the DZA-induced...
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TNF-alpha Downregulates E-cadherin and Sensitizes Response to gamma-irradiation in Caco-2 Cells

Yi JY, Jung YJ, Choi SS, Chung E

  • KMID: 2128578
  • Cancer Res Treat.
  • 2009 Sep;41(3):164-170.
PURPOSE: The purpose of the present study was to assess the biological effects of TNF-alpha in Caco-2 well-differentiated colon adenocarcinoma cells and to determine radiation sensitivity in order to develop...
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Ellagic Acid Shows Different Anti-proliferative Effects Between the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines

Kim HA, Lee RA, Moon BI, Choe KJ

PURPOSE: It has been demonstrated ellagic acid can inhibit tumor growth. However, the mechanism that elicits the anti-proliferative effect of ellagic acid is poorly understood. Our objective in this study...
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Endothelin A Receptor Blockade Influences Apoptosis and Cellular Proliferation in the Developing Rat Kidney

Yoo KH, Yim HE, Jang GY, Bae IS, Choi BM, Hong YS, Lee JW

Endothelin systems are believed to play important roles in the emergence and maintenance of functions of various organs during perinatal development, including the kidney. The present study was designed to...
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Immunohistochemical Expression of Bcl-2, Bcl-xL, Bax, p53 Proteins in Gastric Adenoma and Adenocarcinoma

Lee DS, Kang SB, Baek JT, Nam SW, Lee KM, Ahn BM, Lee EH, Han SW, Chung IS

  • KMID: 772786
  • Korean J Gastroenterol.
  • 2005 Jun;45(6):394-400.
BACKGROUND/AIMS: The aim of this study was to investigate the immunohistochemical expression of bcl-2, bcl-xL, bax, and p53 proteins according to the pathological parameters such as grade of dysplasia,...
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Apoptosis of Prostate Cancer by Inhibition of Bcl-xL Expression

Kwak C, Jeong H, Kim JH, Lee ES, Lee SE

  • KMID: 2293491
  • Korean J Urol.
  • 2004 May;45(5):463-471.
PURPOSE: In this study, we evaluated in vitro whether the anti-sense transfection that was targeted against Bcl-xL would induce cytotoxicity via apoptosis in prostate cancer cells. MATERIALS AND METHODS: cDNA of...
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Increased Viability by Over-Expression of Bcl-XL in a Human Neural Progenitor Cell Line

Ahn YH, Shin YS, Yoon SH, Cho KH, Cho KG, Kim SU

  • KMID: 2188953
  • J Korean Neurosurg Soc.
  • 2004 Apr;35(4):415-421.
OBJECTIVE: This study is aimed whether bcl-xl could protect C4 cells from the cell death induced by serum deprivation. METHODS: The transient transfection of the bcl-xl gene was made with...
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The Preventive Effects of Bcl-2 and Bcl-xL on Lovastatin-induced Apoptosis of C6 Glial Cells

Choi JW, Lee JM, Oh YJ

  • KMID: 2285257
  • Korean J Physiol Pharmacol.
  • 2002 Oct;6(5):235-240.
It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented...
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TGF-beta1 inhibition of apoptosis through the transcriptional up-regulation of Bcl-X(L) in human monocytic leukemia U937 cells

Lee JH, Park BJ, Park JH, Yang MH, Chi SG

  • KMID: 755040
  • Exp Mol Med.
  • 1999 Sep;31(3):126-133.
To characterize the TGF-beta1 response of monocytic leukemia cells, we analyzed the effects of TGF-beta1 on cell proliferation, differentiation, and apoptosis of human monoblastic U937 cells. Treatment of cells with TGF-beta1 in...
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The Role of Apoptosis in the Closure of Human Umbilical Vessels at Birth and Its Mechanism

Hwang KK, Kim HS, Seo JU, Chae IH, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Seo JD, Lee YW

  • KMID: 1558485
  • Korean J Med.
  • 1998 Dec;55(6):991-1004.
BACKGROUND: The mechanism of the closure of umbilical vessels is known to be multifactorial. In order to verify that apoptosis is one of the possible closure mechanisms, we studied to...
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