Korean J Physiol Pharmacol.  2001 Apr;5(2):183-188.

Antidiabetic activity and mechanisms of acarbose in KKAy mice

• Kim YL
• Chung SH

Abstract

To elucidate antidiabetic effect and mechanism(s) of acarbose in a polygenic spontaneous hyperglycemic and hyperinsulinemic diabetic animal model, KKAy mice, acarbose was administered orally for 4 weeks and effects on body weight, plasma glucose and insulin levels, genetic expressions of intestinal sucrase-isomaltase (SI), sodium-glucose cotransporter (sGLT1) and glucose transporter in quadriceps muscle (GLUT4) were examined in this study. Although no differences in body weight were detected between control and acarbose-treated groups, plasma glucose level in acarbose-treated group was markedly reduced as compared to the control. In the mechanism study, acarbose downregulated the SI and SGLT1 gene expressions, and upregulated the GLUT4 mRNA and protein expressions when compared to the control group. In conclusion, the data obtained strongly implicate that acarbose can prevent the hyperglycemia in KKAy mice possibly through blocking intestinal glucose absorption by downregulations of SI and sGLT1 mRNA expressions, and upregulation of skeletal muscle GLUT4 mRNA and protein expressions.

Keyword

Acarbose; KKAy mouse; Sucrase-isomaltase (SI); sGLT1; GLUT4

MeSH Terms

Absorption
Acarbose*
Animals
Blood Glucose
Body Weight
Gene Expression
Glucose
Glucose Transport Proteins, Facilitative
Hyperglycemia
Insulin
Mice*
Models, Animal
Muscle, Skeletal
Quadriceps Muscle
RNA, Messenger
Up-Regulation
Acarbose
Glucose
Glucose Transport Proteins, Facilitative
Insulin
RNA, Messenger