Korean J Pediatr.
2011 Aug;54(8):329-334. 10.3345/kjp.2011.54.8.329.
Clinical characteristics and outcomes among pediatric patients hospitalized with pandemic influenza A/H1N1 2009 infection
- Affiliations
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- 1Department of Pediatrics, Asan Medical Center Children's Hospital, Seoul, Korea. sjhong@amc.seoul.kr
- 2Childhood Asthma Atopy Center, Asan Medical Center Children's Hospital, Seoul, Korea.
- 3Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 4Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
- 5Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea.
- KMID: 2284327
- DOI: http://doi.org/10.3345/kjp.2011.54.8.329
Abstract
- PURPOSE
The purpose of this article is to describe the clinical and epidemiologic features and outcomes among children hospitalized with pandemic influenza A/H1N1 2009 infection.
METHODS
We retrospectively reviewed the charts of hospitalized pediatric patients (<18 years) diagnosed with pandemic influenza A/H1N1 2009 infection by reverse-transcriptase polymerase chain reaction at a tertiary hospital in Seoul, Korea, between September 2009 and February 2010.
RESULTS
A total of 72 children were hospitalized with pandemic influenza A/H1N1 2009 infection (median age, 6.0 years; range, 2 months to 18 years). A total of 40% had at least 1 underlying medical condition, including asthma (17%), malignancies (19%), and heart diseases (17%). Of the 72 patients, 54 (76%) children admitted with H1N1 infection showed radiographic alterations compatible with pneumonia. There was no significant difference in pre-existing conditions between pandemic influenza A/H1N1 infected patients with or without pneumonia. Children with pandemic influenza A/H1N1 pneumonia were more likely to have a lower lymphocyte ratio (P=0.02), higher platelet count (P=0.02), and higher level of serum glucose (P=0.003), and more commonly presented with dyspnea than did those without pneumonia (P=0.04).
CONCLUSION
No significant differences in age, sex, or presence of preexisting conditions were found between children hospitalized with pandemic influenza A/H1N1 H1N1 influenza infection with pneumonia and those without pneumonia. Higher leukocyte count, higher glucose level, and a lower lymphocyte ratio were associated with the development of pandemic A/H1N1 2009 influenza pneumonia.
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