Korean J Pediatr.
2008 May;51(5):528-532. 10.3345/kjp.2008.51.5.528.
Autoimmune hepatitis and thyroiditis associated with antituberculous medications: A case report
- Affiliations
-
- 1Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, Korea. jsmoon@ilsanpaik.ac.kr
- 2Department of Pathology, Inje University Ilsan Paik Hospital, Goyang, Korea.
- KMID: 2280461
- DOI: http://doi.org/10.3345/kjp.2008.51.5.528
Abstract
- Drug-induced toxic hepatitis is a relatively common hepatic disease in children, and it is usually self-limiting upon cessation of the offending drugs. Antituberculous drugs are well known for inducing hepatitis. Some cases of drug-induced hepatitis with autoimmune features have been reported; in these cases, the offending drugs were usually methyldopa, nitrofurantoin, minocycline, and interferon. The authors report the first case in Korea of drug-induced autoimmune hepatitis associated with thyroiditis and multiple autoantibodies that was induced by the antituberculous drugs isoniazid and rifampin.
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