Korean J Pediatr Hematol Oncol.  2004 Oct;11(2):247-252.

A Case of Bronchiolitis Obliterans Organizing Pneumonia Developed after Treatment of Acute Myelogenous Leukemia (M2) with Chloroma and Retinopathy

Affiliations
  • 1Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea. kimhs@dsmc.or.kr
  • 2Department of Diagnostic Radiology, Keimyung University School of Medicine, Daegu, Korea.
  • 3Department of Ophthalmology, Keimyung University School of Medicine, Daegu, Korea.
  • 4Department of Pathology, Keimyung University School of Medicine, Daegu, Korea.

Abstract

Chloroma, a tumor consisted of primitive myeloid cells and located in extramedullary tissues, usually develops during or preceding the course of systemic leukemia, particularly acute myelogenous leukemia (FAB M2) with translocation between chromosomes 8 and 21. Leukemic retinopathy which observed rarely in children than adults, generally related to thrombocytopenia and anemia in leukemic patients. Bronchiolitis obliterans organizing pneumonia (BOOP) is unusual clinicopathologic syndrome in association with a variety of causes or conditions, and histologically defined by the presentation of granulation tissue plugs consisting of fibroblasts and collagen within the lumen of the distal air space. We experienced a 12-year old girl who presented with weakness and ocular pain. She was diagnosed with acute myeloid leukemia with chloroma and retinopathy, and treated with chemotherapy (daunomycin, ara-C, thioguanine, etoposide. mitoxantrone, cyclosporin). Five weeks after the chemotherapy, she developed coughing and persistent fever, and diagnosed with BOOP, which resolved completely after prednisolone therapy.

Keyword

Chloroma; Retinopathy; Bronchiolitis obliterans organizing pneumonia; Chemotherapy; Leukemia; Child

MeSH Terms

Adult
Anemia
Bronchiolitis Obliterans*
Bronchiolitis*
Child
Collagen
Cough
Cryptogenic Organizing Pneumonia*
Cytarabine
Drug Therapy
Etoposide
Female
Fever
Fibroblasts
Granulation Tissue
Humans
Leukemia
Leukemia, Myeloid, Acute*
Mitoxantrone
Myeloid Cells
Prednisolone
Sarcoma, Myeloid*
Thioguanine
Thrombocytopenia
Collagen
Cytarabine
Etoposide
Mitoxantrone
Prednisolone
Thioguanine
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