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Comparison Between the SFTS-QS Kit and the PowerChek SFTSV Real-time PCR Kit for the Detection of Severe Fever With Thrombocytopenia Syndrome Virus

Yoo IY, Kim JY, Yoon YK, Huh HJ, Lee NY

The recent increase in severe fever with thrombocytopenia syndrome (SFTS) cases has led to the development of the SFTS-QS kit (MiCoBioMed, Seongnam, Korea) for detecting the SFTS virus (SFTSV, now...
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Clinical Score System to Differentiate Severe Fever with Thrombocytopenia Syndrome Patients from Patients with Scrub Typhus or Hemorrhagic Fever with Renal Syndrome in Korea

Heo DH, Kang YM, Song KH, Seo JW, Kim JH, Chun JY, Jun KI, Kang CK, Moon SM, Choe PG, Park WB, Bang JH, Kim ES, Kim HB, Park SW, Oh WS, Kim NJ, Oh MD

BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality in East Asia. This study aimed to develop, for primary care providers, a prediction score...
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Severe Cutaneous Adverse Reactions to Antiepileptic Drugs: A Nationwide Registry-Based Study in Korea

Park CS, Kang DY, Kang MG, Kim S, Ye YM, Kim SH, Park HK, Park JW, Nam YH, Yang MS, Jee YK, Jung JW, Kim SH, Kim CW, Kim MY, Kim JH, Lee J, Lee JG, Kim SH, La HO, Kim MH, Park SJ, Koh YI, Lee SM, Kwon YE, Jin HJ, Kim HK, Kang HR, Choi JH, Korean Registry of Severe Cutaneous Adverse Reactions Consortium

PURPOSE: Severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) to antiepileptic drug (AED), are rare, but...
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Long-Term Efficacy and Safety of Partial Splenic Embolization in Hepatocellular Carcinoma Patients with Thrombocytopenia Who Underwent Transarterial Chemoembolization

Kim NH, Kim HJ, Cho YK, Hong HP, Kim BI

BACKGROUND: Performing transarterial chemoembolization (TACE) is difficult with the occurrence of thrombocytopenia in cirrhotic patients with hepatocellular carcinoma (HCC). We aimed to evaluate the long-term efficacy and safety of partial...
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Hemarthrosis Occurred after Arthroscopic Rotator Cuff Repair in a Chronic Renal Failure Patient with a Stenosis in an Ipsilateral Arteriovenous Fistula

Huh SH, Kim SJ, Park JY, Kang KR

Hemarthrosis occurring after arthroscopic surgery for lesions of the shoulder joint is a very rare complication that can develop due to an injury to the blood vessels when an anterior...
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Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome

Yoo JR, Kim SH, Kim YR, Lee KH, Oh WS, Heo ST

BACKGROUND/AIMS: Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever with a high fatality rate. However, effective treatments for SFTS cases not responded to supportive therapy have not...
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The Effect of Mycophenolate Mofetil on Non-Renal Manifestations in Systemic Lupus Erythematosus: Results from Korean Lupus Network Registry

Jung UH, Kwak SG, Choe JY, Lee SS, Kim SK

BACKGROUND: The objective of this study was to identify the effects of mycophenolate mofetil (MMF) on non-renal manifestations in systemic lupus erythematosus (SLE). METHODS: The study population comprised 439 SLE patients...
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Tocilizumab-induced Thrombocytopenia in Patients with Rheumatoid Arthritis

Lee JS, Oh JS, Hong S, Lee CK, Yoo B, Kim YG

OBJECTIVE: Interlukin-6 (IL-6) increases platelet count during inflammation and may act in a manner similar to thrombopoietin. Tocilizumab is a monoclonal antibody of the IL-6 receptor and widely used in...
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Characteristics of blood tests in patients with acute cerebral infarction who developed symptomatic intracranial hemorrhage after intravenous administration of recombinant tissue plasminogen activator

Lee C, Na JU, Lee JH, Han SK, Choi PC, Lee YH, Park SO, Shin DH

OBJECTIVE: Patients suspected as having acute ischemic stroke usually undergo blood tests, including coagulation-related indexes, because thrombocytopenia and coagulopathy are contraindications for recombinant tissue plasminogen activator (rtPA) administration. We aimed...
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A case of hemophagocytic lymphohistiocytosis caused by an Epstein-Barr virus infection, presenting with unremitting fever and rash

Oh SB, Koh CY

Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by excessive activation of lymphocytes and macrophages, leading to cytokine storm. Infection-associated HLH is most common, and Epstein-Barr virus is the leading...
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A Case of Hemolytic Uremic Syndrome after Appendectomy

Kim L, Jung HL, Shim JY, Kim DS, Shim JW, Han YJ, Kwak JH

Hemolytic uremic syndrome (HUS) is associated with consumption of under cooked gound beef, characterized by triad of renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Early recognition of this disease, maintenance...
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Differences of clinical manifestation of severe fever with thrombocytopenia syndrome between Korean and Chinese patients

Bae JM

Because the case fatality rate (CFR) between Chinese and Korean patients with severe fever with thrombocytopenia syndrome is different, a comparison of the distribution of clinical manifestations shown at diagnosis...
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Higher Fatality for Severe Fever with Thrombocytopenia Syndrome Complicated by Hemophagocytic Lymphohistiocytosis

Jung IY, Ahn K, Kim J, Choi JY, Kim HY, Uh Y, Kim YK

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious zoonosis caused by the SFTS virus. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome associated with excessive immune activation. Cytokine storms...
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Epidemiological and Clinical Characteristics of Confirmed Cases of Severe Fever With Thrombocytopenia Syndrome in Jeju Province, Korea, 2014-2018

Kim J, Bae JM

OBJECTIVES: Jeju Province is well known as the region showing the highest incidence of severe fever with thrombocytopenia syndrome (SFTS) in South Korea. The aim of this study was to...
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Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma

Yoo C, Kang J, Lim HY, Kim JH, Lee MA, Lee KH, Kim TY, Ryoo BY

PURPOSE: The signal transducer and activator of transcription 3 (STAT3) signaling pathway might be a promising therapeutic target for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This study was a multicenter, open-label,...
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Association between Medical Costs and the ProVent Model in Patients Requiring Prolonged Mechanical Ventilation

Roh J, Shin MJ, Jeong ES, Lee K

BACKGROUND: The purpose of this study was to determine whether components of the ProVent model can predict the high medical costs in Korean patients requiring at least 21 days of...
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Atypical Hemolytic Uremic Syndrome in a 13-year-old Lao Girl: A Case Report

Kedsatha P, Cheong HI, Choi Y

Atypical hemolytic uremic syndrome (aHUS), a rare form of thrombotic microangiopathy, is distinguished from the typical form by the absence of a preceding verotoxin-producing Escherichia coli infection. Notably, aHUS occurs...
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A case of immune-mediated type 1 diabetes mellitus due to congenital rubella ınfection

Korkmaz HA, ErmiÅŸ C

Congenital rubella infection is a transplacental infection that can cause intrauterine growth retardation, cataracts, patent ductus arteriosus, hearing loss, microcephaly, thrombocytopenia, and severe fetal injury. It has been shown that...
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A Case of Hemostatic Disorder Due to Thrombocytopenia Caused by a Type B Dialysis Reaction

Kim BK, Lee JH

The biocompatibility of dialysis membranes has significantly reduced adverse responses to dialysis, such that nowadays they are rarely reported. We report the case of a patient diagnosed and subsequently treated...
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Differential Diagnosis and Treatment of Thrombotic Microangiopathy Syndrome

Hong J

Diagnosis of thrombotic microangiopathy (TMA) is challenging due to its close association with other forms of microangiopathic hemolytic anemia, such as malignant hypertension and disseminated intravascular coagulation, and because other...
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