Korean J Pain.  2006 Dec;19(2):285-287. 10.3344/kjp.2006.19.2.285.

Naproxen-induced Immune Thrombocytopenia: A case report

• Kim CK
• Jang IS
• Lee JH
• Kwon YE
• Park SC

• KMID: 2073949
• DOI: http://doi.org/10.3344/kjp.2006.19.2.285

Abstract

Hundreds of drugs have been implicated as the causes of antibody-mediated thrombocytopenia. Naproxen is a commonly used nonsteroidal anti-inflammatory drug, and it is generally considered to be safe with few hematological side effects such as thrombocytopenia. In this case, severe thrombocytopenia associated with petechia and epistaxis appeared after initiation of naproxen therapy in the 59-year-old man. We report here on a case of severe thrombocytopenia that was recognized at 10 days after the use of naproxen, and the patient rapidly recovered to a normal platelet count without bleeding symptoms or any complications, although immunoglobulin or steroid was not used.

Keyword

immune; naproxen; thrombocytopenia

MeSH Terms

Epistaxis
Hemorrhage
Humans
Immunoglobulins
Middle Aged
Naproxen
Platelet Count
Thrombocytopenia*
Immunoglobulins
Naproxen