Clin Pediatr Hematol Oncol.  2019 Oct;26(2):67-76. 10.15264/cpho.2019.26.2.67.

Neonatal Thrombocytopenia: Diagnostic Approach and Platelet Transfusion Guideline

• Kim JS
• Kim JY

• KMID: 2464252
• DOI: http://doi.org/10.15264/cpho.2019.26.2.67

Abstract

Neonatal thrombocytopenia, defined as platelet counts of less than 150,000/µL, is a frequent hematologic abnormality in neonatal period. Differential diagnosis of neonatal thrombocytopenia may be challenging to pediatric hematologists and neonatologists because neonatal thrombocytopenia is associated with diverse maternal or neonatal clinical conditions. An accurate diagnosis for neonatal thrombocytopenia will lead to appropriate evaluation and management. Platelet transfusion is the primary management of neonatal thrombocytopenia. Most thrombocytopenic newborns received platelet concentrates to prevent major hemorrhage or treat ongoing bleeding according to institutional policy. However, scientific evidences for benefit and consistent guideline for platelet transfusion in neonates are lacking, further investigation to establish the standard recommendation for platelet transfusion is needed. This article reviewed the diagnostic approach and current guideline for platelet transfusion management for neonatal thrombocytopenia.

Keyword

Neonate; Infant; Thrombocytopenia; Platelets; Transfusion

MeSH Terms

Blood Platelets*
Diagnosis
Diagnosis, Differential
Hemorrhage
Humans
Infant
Infant, Newborn
Organizational Policy
Platelet Count
Platelet Transfusion*
Thrombocytopenia
Thrombocytopenia, Neonatal Alloimmune*