The Clinical Features and Neonatal Outcomes of Thrombocytopenia in Pregnancy

Jun, Kyung Chul; Hyung, Woo Jin; Choi, Hyung Min

Abstract

OBJECTIVE: The aim of this study was to evaluate the proper management based on 6 years of experience in Inje University Ilsan Paik Hospital by review of the clinical features of thrombocytopenia in pregnancy. METHODS: A survey about causing factors, diagnosis, obstetric outcomes and management of thrombocytopenia in pregnancy at Inje University Ilsan Paik Hospital from December 1999 to September 2005 was done by retrospectively. RESULTS: The total number of delivery was 3002 and total number of thrombocytopenia in pregnancy was 70 (2.3%), of which 37 were gestational thrombocytopenia and 10 were ITP. The thrombocytopenia associated with PIH was 21, pancytopenia was 1 case, and thrombocytopenia associated with liver cirrhosis was 1 case. The obstetric and perinatal outcomes were similar between groups. But 1 case of ITP pregnancy, there was neonatal intraventricular hemorrhage was observed. CONCLUSION: Gestational thrombocytopenia is the most common cause of thrombocytopenia. It is characterized by mild maternal thrombocytopenia and is not associated with adverse maternal or fetal outcomes. The ITP patients should be carefully monitored during the antenatal care visits, also preeclampsia, HELLP, and the primary thrombotic microangiopathies need careful monitoring, but these disease can be differentiated from one another in most cases.