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Prognostic utility of ADAMTS13 activity for the atypical hemolytic uremic syndrome (aHUS) and comparison of complement serology between aHUS and thrombotic thrombocytopenic purpura

Oh J, Oh D, Lee SJ, Kim JO, Kim NK, Chong SY, Huh JY, Baker RI, on behalf of the Korean TTP Registry Investigators

BACKGROUND: Atypical hemolytic uremic syndrome (aHUS) involves dysregulation of the complement system, but whether this also occurs in thrombotic thrombocytopenic purpura (TTP) remains unclear. Although these conditions are difficult to...
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Atypical Hemolytic Uremic Syndrome in a 13-year-old Lao Girl: A Case Report

Kedsatha P, Cheong HI, Choi Y

Atypical hemolytic uremic syndrome (aHUS), a rare form of thrombotic microangiopathy, is distinguished from the typical form by the absence of a preceding verotoxin-producing Escherichia coli infection. Notably, aHUS occurs...
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Differential Diagnosis and Treatment of Thrombotic Microangiopathy Syndrome

Hong J

Diagnosis of thrombotic microangiopathy (TMA) is challenging due to its close association with other forms of microangiopathic hemolytic anemia, such as malignant hypertension and disseminated intravascular coagulation, and because other...
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Sudden Unexpected Death During Bronchoscopy of a Patient with Pulmonary Lymphangitic Carcinomatosis and Pulmonary Tumor Thrombotic Microangiopathy due to Gastric Cancer

Park S, Na JY, Choi BH

We present the case of a 48-year-old woman who complained of sustained dyspnea and newly developed dyspnea, who then suddenly and unexpectedly expired during bronchoscopy. On postmortem examination, the deceased...
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Therapeutic Plasma Exchange in a Patient with Hemophagocytic Lymphohistiocytosis

Roh J, Kim S, Nah H, Lee K, Kim HO

A 22-year old female patient with systemic lupus erythematosus presenting microangiopathic hemolytic anemia was treated with therapeutic plasma exchange 23 times. The patient's condition and laboratory findings (aspartate aminotransferase, alanine...
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Clinical characteristics and outcomes of thrombotic microangiopathy in Malaysia

Yap YY, Sathar J, Law KB, Zulkurnain PAB, Edmund SC, Chang KM, Baker R

BACKGROUND: Thrombotic microangiopathy (TMA) with non-deficient ADAMTS-13 (a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13) outcome is unknown hence the survival analysis correlating with ADAMTS-13 activity is conducted...
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A first case of high-flow nasal cannula oxygen therapy in patients with pulmonary tumor thrombotic microangiopathy

Joo H, Na DH, Seung J, Kim TY, Min GJ, Rhee CK

No abstract available.
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Acute cor pulmonale due to pulmonary tumor thrombotic microangiopathy in two patients with breast cancer

Moon SY, Lee KH, Lee JS, Yang HS, Lee HG, Cho YH, Yoon SY

No abstract available.
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Tacrolimus-induced, Transplant-associated Thrombotic Microangiopathies after Lung Transplantation

Choi JS, Kim SY, Lee JG, Kim SJ, Song MJ, Yoon BR, Kim MH, Park MS, Paik HC

We report a case of tacrolimus-induced transplant-associated thrombotic microangiopathies (TA-TMA) after lung transplantation. A 71-year-old man underwent lung transplantation secondary to idiopathic pulmonary fibrosis. After 4 months, he presented with...
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Overcome of Drug Induced Thrombotic Microangiopathy after Kidney Transplantation by Using Belatacept for Maintenance Immunosuppression

Yun SH, Lee JH, Oh JS, Kim SM, Sin YH, Kim YJ, Kim JK

Thrombotic microangiopathy (TMA) is a serious complication of solid organ transplantation. Drug-induced TMA is typically caused by immunosuppressants, particularly calcineurin inhibitors. Withdrawing the causative drug can be one of the...
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A Case Report: Cavitary Infarction Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Pancreatic Intraductal Papillary Mucinous Neoplasm

Bae K, Kwon WJ, Choi SH, Lee JH, Cha HJ

Pulmonary tumor embolism is commonly discovered at autopsy, but is rarely suspected ante-mortem. Microangiopathy is an uncommon and distinct form of simple tumor pulmonary embolism. Here, we present a 52-year-old...
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A case of gemcitabine-induced thrombotic microangiopathy in a urothelial tumor patient with a single kidney

Ryu H, Kang E, Park S, Park S, Lee K, Joo KW, Lee H

Thrombotic microangiopathy (TMA) is a rare complication of gemcitabine treatment. A 55-year-old man with a history of urothelial cancer underwent right ureteronephrectomy and palliative chemotherapy. The patient presented with dyspnea,...
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Successful Treatment with Low-dose Rituximab in a Patient with Plasma Exchange-refractory Idiopathic Thrombotic Thrombocytopenic Purpura

Song KH, Hong J, Hwang H, Kang E, Park J, Ahn JY, Lee JH

Thrombotic thrombocytopenic purpura (TTP) is a clinical syndrome characterized by micro-angiopathic hemolytic anemia, thrombocytopenia, fever, renal disorders, and neurological manifestations. Its clinical course is rapid and the mortality rate is...
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Antiphospholipid Syndrome Presenting as Recurrent Pancreatitis and Renal Thrombotic Microangiopathy

Lee HK, Jeong SO, Kim Y, Jin SY, Kim HS, Cho YD

Antiphospholipid syndrome (APS) is characterized by vascular thrombosis or recurrent fetal loss in the presence of antiphospholipid antibodies. APS has various manifestations because it can involve any vessel in most...
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Pulmonary Tumor Thrombotic Microangiopathy Associated with Advanced Gastric Cancer Successfully Treated with Chemotherapy

Yoo SH, Park K, Hong JY, Kim JY, Park JW, Park YW, Lee KH, Jeon KS

Pulmonary tumor thrombotic microangiopathy (PTTM) is an uncommon and fatal malignancy-related pulmonary complication characterized by fibrocellular intimal proliferation of small pulmonary arteries and arterioles. It causes marked pulmonary hypertension, right-side...
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Occult Gastric Cancer Presenting as Hypoxia from Pulmonary Tumor Thrombotic Microangiopathy

Mandaliya , Farhat S, Uprety D, Balla M, Gandhi A, Goldhahn R, Auerbach H, Christensen C, Reed C, Cohen S

  • KMID: 2372524
  • J Gastric Cancer.
  • 2014 Jun;14(2):142-146.
Pulmonary tumor thrombotic microangiopathy (PTTM) causing fatal pulmonary hypertension is a rare presentation of malignancy. In general, patients with PTTM rapidly succumb to death due to severe hypoxia. To date,...
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Thrombotic microangiopathy resulting from neglected blood pressure control

Ku JS, Kim W, Lee S, Kang MJ, Park SK, Kang KP

  • KMID: 2224274
  • Kidney Res Clin Pract.
  • 2014 Jun;33(2):103-105.
Hypertensive nephrosclerosis is usually associated with chronic hypertension, which increases the risk of progressive renal disease. Among the causes of malignant hypertension, thrombotic microangiopathy is complicated and is associated with...
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A Case of Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Advanced Gastric Cancer

Jun JE, Kim JH, Ryu DH, Lee JE, Jeong HJ, Yang JH

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare and fatal cancer-related pulmonary complication leading to severe pulmonary hypertension, right heart failure, and death. Few cases of PTTM have been diagnosed...
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A Case of Thrombotic Microangiopathy Following Autologous Stem Cell Transplantation

Choi JY, Lee JW, Ju HY, Hong CR, Kim H, Lee DS, Kim NH, Kang HJ, Park KD, Shin HY

Transplantation-associated thrombotic microangiopathy (TA-TMA) is an uncommon but devastating complication in patients who undergo hematopoietic stem cell transplantation (SCT). However, the optimal treatment strategy for TA-TMA is unclear. We report...
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Pathology of Thrombotic Microangiopathy

Sol MY

  • KMID: 2196618
  • J Korean Soc Pediatr Nephrol.
  • 2013 Apr;17(1):6-12.
Thrombotic microangiopathy (TMA) is a microvascular thrombotic lesion caused by endothelial injury and subsequent formation of platelet rich thrombus. TMA is first described as a classical pathologic feature of HUS/TTP....
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