Korean J Gastroenterol.  2011 Mar;57(3):198-200. 10.4166/kjg.2011.57.3.198.

Intestinal Thrombotic Microangiopathy after Liver Transplantation

Affiliations
  • 1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 2Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kkmkys@skku.edu

Abstract

No abstract available.


MeSH Terms

Acute Disease
Antiviral Agents/therapeutic use
Colon/pathology
Colonoscopy
DNA, Viral/blood
Enzyme Inhibitors/therapeutic use
Ganciclovir/therapeutic use
Hepatitis B/diagnosis
Humans
Immunosuppressive Agents/adverse effects/therapeutic use
*Liver Transplantation
Male
Middle Aged
Mycophenolic Acid/therapeutic use
Tacrolimus/adverse effects/therapeutic use
Thrombotic Microangiopathies/chemically induced/*etiology/pathology

Figure

  • Fig. 1. Colonoscopic findings in the descending colon (A) and sigmoid colon (B) showed longitudinal ulcerations and erythematous mucosal changes which mimicked ischemic colitis.

  • Fig. 2. Pathologic findings of colon biopsy. (A) It showed denuded mucosa with mucosal congestion and hemorrhage (H&E, ×100) (B) with micro-thrombi (arrows) in capillaries with swollen and detached endothelial cells (H&E, ×400).


Reference

References

1. Jung YS, Kim HY, Yook DS, Chun BK, Hwang IY, Rim H. 3 cases of thrombotic microangiopathy induced by low dose mitomy-cin-c. Korean J Nephrol. 2003; 22:135–141.
2. Rizza V, Coletti G, Mazzotta C, et al. A rare case of colic thrombotic microangiopathy in renal transplantation. Transplant Proc. 2010; 42:1362–1364.
Article
3. Dong LJ, Xie DH, Lu DP, et al. HSC transplantation-associated intestinal thrombotic microangiopathy: clinical pathological features, diagnosis criteria and treatment. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006; 14:327–331.
4. Dierickx D, Monbaliu D, De Rycke A, et al. Thrombotic microangiopathy following intestinal transplantation: a single center experience. Transplant Proc. 2010; 42:79–81.
Article
5. Narimatsu H, Kami M, Hara S, et al. Intestinal thrombotic microangiopathy following reduced-intensity umbilical cord blood transplantation. Bone Marrow Transplant. 2005; 36:517–523.
Article
6. Fujino M, Kim Y, Ito M. Intestinal thrombotic microangiopathy induced by FK506 in rats. Bone Marrow Transplant. 2007; 39:367–372.
Article
7. Pham PT, Peng A, Wilkinson AH, et al. Cyclosporine and tacroli-mus-associated thrombotic microangiopathy. Am J Kidney Dis. 2000; 36:844–850.
Article
8. Takatsuka H, Wakae T, Mori A, et al. Endothelial damage caused by cytomegalovirus and human herpesvirus-6. Bone Marrow Transplant. 2003; 31:475–479.
Article
9. Yamamoto S, Nakase H, Chiba T, Yamashita K, Ito M. Clinical challenges and images in GI. Image 4. Transplant-associated thrombotic microangiopathy of the colon accompanied by graft-versus-host disease. Gastroenterology. 2009; 136:2067–2418.
10. Kim GM, Cheung DY, Kim JI. Gastrointestinal complication in transplant patients. Korean J Gastrointest Endosc. 2010; 41:65–71.
11. Nishida T, Hamaguchi M, Hirabayashi N, et al. Intestinal thrombotic microangiopathy after allogeneic bone marrow transplantation: a clinical imitator of acute enteric graft-versus-host disease. Bone Marrow Transplant. 2004; 33:1143–1150.
Article
12. Komeno Y, Ogawa S, Ishida T, et al. Ischemic colitis as a manifestation of thrombotic microangiopathy following bone marrow transplantation. Intern Med. 2003; 42:1228–1232.
Article
Full Text Links
  • KJG
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr