Korean J Pathol.
2010 Aug;44(4):431-434.
Exuberant Smooth Muscle Cells in Fibroadenoma of the Breast: A Case Report
- Affiliations
-
- 1Department of Pathology, Chonnam National University Medical School, Gwangju, Korea. jshinlee@hanmail.net
- 2Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
Abstract
- Smooth muscle cell metaplasia is an extremely rare form of stromal differentiation in fibroadenomas. We describe a case of fibroadenoma with exuberant smooth muscle cells in a 72-year-old woman. The mass was located in the upper central portion of the left breast. It was well circumscribed and its greatest dimension was 3 cm. Histologically, the glandular elements resembled the appearance of fibroadenoma, but the stromal elements were composed of spindle cell bundles with abundant eosinophilic cytoplasm and elongated cigar-shaped nuclei. Neither mitotic activity nor cellular atypia was seen. The stromal cells were immunohistochemically positive for smooth muscle actin, calponin, desmin, and estrogen receptor-beta, but negative for CD34, S-100 protein, p63, CD10, estrogen receptor-alpha, progesterone receptor and cytokeratin. These results proved that the stromal cells showed features of smooth muscle cells.
Keyword
MeSH Terms
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Actins
Aged
Breast
Calcium-Binding Proteins
Cytoplasm
Desmin
Eosinophils
Estrogens
Female
Fibroadenoma
Humans
Keratins
Metaplasia
Microfilament Proteins
Muscle Cells
Muscle, Smooth
Myocytes, Smooth Muscle
Receptors, Progesterone
S100 Proteins
Stromal Cells
Actins
Calcium-Binding Proteins
Desmin
Estrogens
Keratins
Microfilament Proteins
Receptors, Progesterone
S100 Proteins
