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A Case of Solitary Fibrous Tumor of Subungual Region

An MK, Hong EH, Cho EB, Park EJ, Kim KH, Kim KJ

Solitary fibrous tumor (SFT) is a relatively uncommon mesenchymal neoplasm that usually arises in the pleura, but also has been reported in numerous extrapleural locations, including cutaneous site. The skin...
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Case Report of Nodular Fasciitis in the Conjunctiva

Kim JH, Na KS, Park CH, Lee SJ, Oh TH, Kim HS

PURPOSE: We report a case of nodular fasciitis of the conjunctiva that has not been previously reported in the Republic of Korea. CASE SUMMARY: A 18-year-old female patient presented with a...
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Primary leiomyosarcoma of the liver: Two new cases and a systematic review

Esposito F, Lim C, Baranes L, Salloum C, Feray C, Calderaro , Azoulay D

Primary hepatic leiomyosarcoma (PHL) is a rare malignant tumor, which originates from smooth muscles. Clinical presentation and imaging features are non-specific and can mimick the most frequent primary liver tumors...
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Duodenal Leiomyosarcoma Presenting with Gastrointestinal Bleeding and Obstruction: A Case Report

Hong SM, Kim GH, Kim D, Lee S

Duodenal leiomyosarcoma is a rare condition with a poor prognosis. Early diagnosis of duodenal leiomyosarcoma is challenging because it presents with nonspecific symptoms and endoscopic biopsies usually do not enable...
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Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity

Nishida M, Tanaka T, Mangmool S, Nishiyama , Nishimura

Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully...
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Decreased inward rectifier and voltage-gated K⁺ currents of the right septal coronary artery smooth muscle cells in pulmonary arterial hypertensive rats

Kim SE, Yin MZ, Kim HJ, Vorn R, Yoo HY, Kim SJ

In vascular smooth muscle, K⁺ channels, such as voltage-gated K⁺ channels (Kv), inward-rectifier K⁺ channels (Kir), and big-conductance Ca²⁺-activated K⁺ channels (BK(Ca)), establish a hyperpolarized membrane potential and counterbalance the...
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Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway

Kim SG, Sung JY, Kim JR, Choi HC

Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance...
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Effect of dyslipidemia on vascular smooth muscle cell proliferation in a porcine coronary restenosis model

Jeong KJ, Kang P, Lee HY, Son HC, Park SH, Choi WS, Koo BS, Jeon CY, Baek SH, An YJ, Kim HK, Kim SS, Park JK, Bae IH, Park DS, Shim JW, Kim JU, Kim NY, Kim SU, Lim KS, Jeong MH

This study aimed to examine the effect of a mild elevation in serum cholesterol level in a porcine coronary overstretch restenosis model using a balloon angioplasty catheter or drug-eluting coronary...
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The relaxant effect of nicardipine on the isolated uterine smooth muscle of the pregnant rat

Kim DJ, Hwang MH, An TH, Jung KT

BACKGROUND: Nicardipine, a calcium channel blocker, is used to treat hypertension in pregnancy or preterm labor. The current study was conducted to investigate the relaxant effects of nicardipine on the...
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Colonic Dysmotility in Murine Partial Colonic Obstruction Due to Functional Changes in Interstitial Cells

Wang Q, Zang J, Huang X, Lu H, Xu W, Chen J

  • KMID: 2460488
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):589-601.
  • doi: 10.5056/jnm19136
BACKGROUND/AIMS: Interstitial cells play important roles in gastrointestinal (GI) neuro-smooth muscle transmission. The underlying mechanisms of colonic dysmotility have not been well illustrated. We established a partial colon obstruction (PCO)...
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Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling

Lee H, Han JH, Kim S, Kim S, Cho DH, Woo CH

OBJECTIVE: The aim of this study was to investigate the effects of 2 anti-malarial drugs, chloroquine (CQ) and hydroxychloroquine (HCQ), on inhibition of vascular smooth muscle cell (VSMC) proliferation both...
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Cotyledonoid dissecting leiomyoma: an uncommon form of a common disease

Jamal I, Gupta RK, Sinha RK, Bhadani PP

Leiomyomas are benign uterine smooth muscle neoplasms with varied morphology that are well known to undergo secondary changes. Cotyledonoid dissecting leiomyoma is a rare and distinct form of leiomyoma that...
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Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma

Hur GY, Broide DH

Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics. Airway remodeling is characterized...
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Carpinus turczaninowii extract modulates arterial inflammatory response: a potential therapeutic use for atherosclerosis

Son YK, Yoon SR, Bang WY, Bae CH, Yeo JH, Yeo R, An J, Song J, Kim OY

BACKGROUND/OBJECTIVES: Vascular inflammation is an important feature in the atherosclerotic process. Recent studies report that leaves and branches of Carpinus turczaninowii (C. turczaninowii) have antioxidant capacity and exert anti-inflammatory effects....
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Adipose Tissue-Derived Stem Cell Therapy for Cavernous Nerve Injury-Induced Erectile Dysfunction in the Rat Model: A Systematic Review and Meta-Analysis Using Methodological Quality Assessment

Park HJ, Jeong H, Park YH, Yim HW, Ha US, Hong SH, Kim SW, Kim NJ, Lee JY

BACKGROUND AND OBJECTIVES: Few studies were evaluated the effect of blindness on outcome in animal models, though a potential effect of blinding has been reported in clinical trials. We evaluated...
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Role of DNA Methylation in the Development and Differentiation of Intestinal Epithelial Cells and Smooth Muscle Cells

Jorgensen , Ro S

  • KMID: 2454636
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):377-386.
  • doi: 10.5056/jnm19077
The mammalian intestine contains many different cell types but is comprised of 2 main cell types: epithelial cells and smooth muscle cells. Recent in vivo and in vitro evidence has...
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Synergistic effects of extracorporeal shockwave therapy and modified Ojayeonjonghwan on erectile dysfunction in an animal model of diabetes

Jeong HC, Bae WJ, Zhu GQ, Jeon SH, Choi SW, Kim SJ, Cho HJ, Hong SH, Lee JY, Hwang SY, Kim SW

PURPOSE: We investigated the synergy effect of extracorporeal shock wave therapy (ESWT) with modified Ojayeonjonghwan (Korean herbal formula, KH-204) in an animal model of diabetes mellitus (DM)-induced erectile dysfunction (ED). MATERIALS...
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Benefits of Angiotensin Receptor Blockade: Preventing Smooth Muscle Cell Senescence and Beyond

Song P, Kim JH

No abstract available.
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Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway

Kim I, Park CS, Lee HY

BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) has been suggested to accelerate vascular senescence, however the molecular mechanism(s) remain unknown. METHODS: We cultured human coronary artery smooth muscle cells (hCSMCs) and...
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Uterine smooth muscle tumor of uncertain malignant potential: fertility and clinical outcomes

Şahin H, Karatas F, Coban G, Özen O, Erdem O, Onan MA, Ayhan A

OBJECTIVE: In this study, we aimed to evaluate the clinicopathological features, obstetric, and oncological outcomes of patients diagnosed with a uterine smooth muscle tumors of uncertain malignant potential (STUMP). METHODS: A...
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