- Antitumor profiles and cardiac electrophysiological effects of aurora kinase inhibitor ZM447439
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Lee HA, Kwon M, Kim HA, Kim KS
- KMID: 2455815
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):393-402.
- doi: 10.4196/kjpp.2019.23.5.393
Aurora kinases inhibitors, including ZM447439 (ZM), which suppress cell division, have attracted a great deal of attention as potential novel anti-cancer drugs. Several recent studies have confirmed the anti-cancer effects... -
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- Profiling of remote skeletal muscle gene changes resulting from stimulation of atopic dermatitis disease in NC/Nga mouse model
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Lee D, Seo Y, Kim YW, Kim S, Choi J, Moon SH, Bae H, Kim HS, Kim H, Kim JH, Kim TY, Kim E, Yim S, Lim I, Bang H, Kim JH, Ko JH
- KMID: 2455813
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):367-379.
- doi: 10.4196/kjpp.2019.23.5.367
Although atopic dermatitis (AD) is known to be a representative skin disorder, it also affects the systemic immune response. In a recent study, myoblasts were shown to be involved in... -
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- Angiotensin II and TGF-β1 Induce Alterations in Human Amniotic Fluid-Derived Mesenchymal Stem Cells Leading to Cardiomyogenic Differentiation Initiation
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GasiÅ«nienÄ— M, Petkus G, MatuzeviÄius D, Navakauskas D, NavakauskienÄ— R
- KMID: 2465896
- Int J Stem Cells.
- 2019 Jul;12(2):251-264.
- doi: 10.15283/ijsc18126
BACKGROUND AND OBJECTIVES: Human amniotic fluid-derived mesenchymal stem cells (AF-MSCs) may be a valuable source for cardiovascular tissue engineering and cell therapy. The aim of this study is to verify... -
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- Novel porcine model of acute myocardial infarction using polyethylene terephthalate
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Kim YS, Kim NY, Bae IH, Park JK, Park DS, Shim JW, Kang WS, Kim HB, Song BS, Koo BS, Jeong KJ, Kim SU, Kim HK, Kim SS, Kim MC, Sim DS, Hong YJ, Ahn Y, Lim KS, Jeong MH
- KMID: 2452876
- J Biomed Transl Res.
- 2019 Jun;20(2):44-52.
- doi: 10.12729/jbtr.2019.20.2.044
Acute myocardial infarction (AMI) is considered the major cause of mortality in the world. Tremendous animal studies are performed to develop novel therapeutics, and this study aimed to induce porcine... -
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- Cortical Bone Derived Stem Cells for Cardiac Wound Healing
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Mohsin S, Houser SR
- KMID: 2441134
- Korean Circ J.
- 2019 Apr;49(4):314-325.
- doi: 10.4070/kcj.2018.0437
Ischemic heart disease can lead to myocardial infarction (MI), a major cause of morbidity and mortality worldwide. Adoptive transfer of multiple stem cell types into failing human hearts has demonstrated... -
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- Fimasartan attenuates renal ischemia-reperfusion injury by modulating inflammation-related apoptosis
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Cho JH, Choi SY, Ryu HM, Oh EJ, Yook JM, Ahn JS, Jung HY, Choi JY, Park SH, Kim CD, Kim YL
- KMID: 2430088
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):661-670.
- doi: 10.4196/kjpp.2018.22.6.661
Fimasartan, a new angiotensin II receptor antagonist, reduces myocyte damage and stabilizes atherosclerotic plaque through its anti-inflammatory effect in animal studies. We investigated the protective effects of pretreatment with fimasartan... -
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- Clinical Characteristics of Rhabdomyolysis in Children : Single Center Experience
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Park Y, Song JY, Kim SY, Kim SH
- KMID: 2435370
- Child Kidney Dis.
- 2018 Oct;22(2):52-57.
- doi: 10.3339/jkspn.2018.22.2.52
PURPOSE: Rhabdomyolysis is a metabolic disorder in which the content of damaged muscle cells is released into plasma. Its manifestations include asymptomatic, myalgia, gross hematuria, and complications of acute kidney... -
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- In Vitro and In Vivo Osteogenesis of Human Orbicularis Oculi Muscle-Derived Stem Cells
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Liu G, Liao C, Chen X, Wu Y
- KMID: 2418101
- Tissue Eng Regen Med.
- 2018 Aug;15(4):445-452.
- doi: 10.1007/s13770-018-0122-1
BACKGROUND: Cell-based therapies for treating bone defects require a source of stem cells with osteogenic potential. There is evidence from pathologic ossification within muscles that human skeletal muscles contain osteogenic... -
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- Histological Changes in Biceps Muscle after Tenotomizing the Biceps Long Head in a Rat Model
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Song HJ, Heu JY, Song HS
- KMID: 2436390
- Clin Should Elbow.
- 2018 Jun;21(2):87-94.
- doi: 10.5397/cise.2018.21.2.87
BACKGROUND: Popeye deformity is common after rupture of the biceps muscle's long head tendon. Herein, we report on histological changes in biceps brachii muscles following tenotomy of the long head... -
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- Effects of Paroxetine on a Human Ether-a-go-go-related Gene (hERG) K⺠Channel Expressed in Xenopus Oocytes and on Cardiac Action Potential
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Hong HK, Hwang S, Jo SH
- KMID: 2437484
- Int J Oral Biol.
- 2018 Mar;43(1):43-51.
- doi: 10.11620/IJOB.2018.43.1.043
K⺠channels are key components of the primary and secondary basolateral Cl- pump systems, which are important for secretion from the salivary glands. Paroxetine is a selective serotonin reuptake inhibitor... -
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- Sumoylation of histone deacetylase 1 regulates MyoD signaling during myogenesis
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Joung H, Kwon S, Kim KH, Lee YG, Shin S, Kwon DH, Lee YU, Kook T, Choe N, Kim JC, Kim YK, Eom GH, Kook H
- KMID: 2438357
- Exp Mol Med.
- 2018 Jan;50(1):e427.
- doi: 10.1038/emm.2017.236
Sumoylation, the conjugation of a small ubiquitin-like modifier (SUMO) protein to a target, has diverse cellular effects. However, the functional roles of the SUMO modification during myogenesis have not been... -
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- Cyclic Stretch Effects on Adipose-Derived Stem Cell Stiffness, Morphology and Smooth Muscle Cell Gene Expression
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Rabbani M, Tafazzoli-Shadpour M, Shokrgozar MA, Janmaleki , Teymoori M
- KMID: 2395084
- Tissue Eng Regen Med.
- 2017 Jun;14(3):279-286.
- doi: 10.1007/s13770-017-0033-6
Recent investigations consider adipose-derived stemcells (ASCs) as a promising source of stemcells for clinical therapies. To obtain functional cells with enhanced cytoskeleton and aligned structure, mechanical stimuli are utilized during... -
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- Ondansetron Inhibits Voltage-Gated K⺠Current of Ventricular Myocytes from Pregnant Mouse
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Cui S, Park H, Park H, Mun D, Kim HE, Yun N, Joung B
- KMID: 2387536
- Int J Arrhythm.
- 2017 Jun;18(2):77-84.
- doi: 10.18501/arrhythmia.2017.012
BACKGROUND: The Htr3a antagonist, ondansetron, has been reported to prolong the QT interval and induce Torsades de pointes in the treatment of postoperative nausea and vomiting. To explore the mechanisms... -
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- Protein tyrosine phosphatase 1B is a mediator of cyclic ADP ribose-induced Ca²⺠signaling in ventricular myocytes
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Park SA, Hong BZ, Ha KC, Kim UH, Han MK, Kwak YG
- KMID: 2386961
- Exp Mol Med.
- 2017 Jun;49(6):e341.
- doi: 10.1038/emm.2017.68
Cyclic ADP-ribose (cADPR) releases Ca²⺠from ryanodine receptor (RyR)-sensitive calcium pools in various cell types. In cardiac myocytes, the physiological levels of cADPR transiently increase the amplitude and frequency of... -
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- Intermuscular Adipose Tissue Content and Intramyocellular Lipid Fatty Acid Saturation Are Associated with Glucose Homeostasis in Middle-Aged and Older Adults
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Kim JE, Dunville K, Li J, Cheng JX, Conley TB, Couture CS, Campbell W
- KMID: 2384085
- Endocrinol Metab.
- 2017 Jun;32(2):257-264.
- doi: 10.3803/EnM.2017.32.2.257
BACKGROUND: Insulin resistance is associated with the higher content of intermuscular adipose tissue (IMAT) and the saturation of intramyocellular lipid (IMCL), but a paucity of data exist in humans. This... -
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- Giant Brunner’s Gland Hamartoma of the Duodenal Bulb Presenting with Upper Gastrointestinal Bleeding and Obstruction
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Lee JH, Jo KM, Kim TO, Park JH, Park SH, Jung JW, Hur SC, Yang SY
- KMID: 2383455
- Clin Endosc.
- 2016 Nov;49(6):570-574.
- doi: 10.5946/ce.2016.022
Brunner’s gland hamartomas are small benign lesions that are most commonly found in the bulb of the duodenum. They are very uncommon, and most are found incidentally during upper gastrointestinal... -
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- TonEBP suppresses adipocyte differentiation via modulation of early signaling in 3T3-L1 cells
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Kim SJ, Kim T, Choi HN, Cho EJ, Park JB, Jeon BH, Lee SD
- KMID: 2364269
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):649-655.
- doi: 10.4196/kjpp.2016.20.6.649
TonEBP belongs to the Rel family of transcription factors and plays important roles in inflammation as well as kidney homeostasis. Recent studies suggest that TonEBP expression is also involved in... -
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- Bioreactor Conditioning of Valve Scaffolds Seeded Internally with Adult Stem Cells
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Kennamer A, Sierad L, Pascal R, Rierson N, Albers C, Harpa M, Cotoi O, Harceaga L, Olah P, Terezia P, Simionescu A, Simionescu D
- KMID: 2360799
- Tissue Eng Regen Med.
- 2016 Oct;13(5):507-515.
- doi: 10.1007/s13770-016-9114-1
The goal of this study was to test the hypothesis that stem cells, as a response to valve-specific extracellular matrix “niches†and mechanical stimuli, would differentiate into valvular interstitial cells... -
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- Macrophage density in pharyngeal and laryngeal muscles greatly exceeds that in other striated muscles: an immunohistochemical study using elderly human cadavers
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Rhee S, Yamamoto M, Kitamura K, Masaaki K, Katori Y, Murakami G, Abe SI
- KMID: 2353342
- Anat Cell Biol.
- 2016 Sep;49(3):177-183.
- doi: 10.5115/acb.2016.49.3.177
Macrophages play an important role in aging-related muscle atrophy (i.e., sarcopenia). We examined macrophage density in six striated muscles (cricopharyngeus muscle, posterior cricoarytenoideus muscle, genioglossus muscle, masseter muscle, infraspinatus muscle,... -
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- Chronic Paraspinal Muscle Injury Model in Rat
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Cho TG, Park SW, Kim YB
- KMID: 2351709
- J Korean Neurosurg Soc.
- 2016 Sep;59(5):430-436.
- doi: 10.3340/jkns.2016.59.5.430
OBJECTIVE: The objective of this study is to establish an animal model of chronic paraspinal muscle injury in rat. METHODS: Fifty four Sprague-Dawley male rats were divided into experimental group (n=30),... -
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