Maxillofac Plast Reconstr Surg.
2016 Aug;38(8):33. 10.1186/s40902-016-0079-8.
S100 and p65 expression are increased in the masseter muscle after botulinum toxin-A injection
- Affiliations
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- 1Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung 210-702, South Korea. kimsg@gwnu.ac.kr
- 2Sericultural and Apicultural Materials Division, National Academy of Agricultural Science, Suwon, South Korea.
- KMID: 2351667
- DOI: http://doi.org/10.1186/s40902-016-0079-8
Abstract
- BACKGROUND
The purpose of this study was to compare the expression levels of p65 and S100 in the rat masseter muscle after the injection of different concentrations of botulinum toxin-A (BTX-A).
METHODS
We injected either 5 or 10 U of BTX-A into both masseter muscle of rats. As a control group, the same volume of saline was injected. After 14 days, the animals were sacrificed. Subsequently, a biopsy and immunohistochemical staining of the samples were performed using a p65 or S100 antibody.
RESULTS
The cross-sectional area of each myofibril was significantly reduced by BTX-A injection (P < 0.001). The expression of p65 and S100 increased significantly with increasing concentrations of BTX-A (P < 0.001).
CONCLUSIONS
The injection of BTX-A into the masseter muscle induced muscle atrophy. Subsequently, p65 and S100 expression in myoblasts were increased for the protection of muscle cells.
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