Yeungnam Univ J Med.
1989 Dec;6(2):13-22. 10.12701/yujm.1989.6.2.13.
The Effects of Diazepam on the Carbachol Induced Contraction of the Isolated Rat Ileum
- KMID: 2377226
- DOI: http://doi.org/10.12701/yujm.1989.6.2.13
Abstract
- To investigate the effect of diazepam on the contractility of the intestinal smooth muscle, longitudinal muscle strip isolated from rat ileum was prepared for myography in isolated organ bath. 1) Basal tone of ileal muscle was reduced by diazepam concentration-dependently. 2) Higher concentrations (30 and 100 microM) of diazepam inhibited (p<0.05, p<0.001) The carbachol-induced contraction in a concentration-dependent manner; but lower concentration of diazepam (10 microM) enhanced (p<0.05). 3) Histamine-induced contraction was inhibited by pretreatment with diazepam in a concentration-dependent manner. 4) Caâºâº-induced tension recovery in calcium-free solution was inhibited in the presence of diazepam concentration-dependently. These results suggest diazepam reduces the contractility of the longitudinal muscle isolated from rat ileum via interference with influx of calcium into the muscle cells.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Effects of Heparin and Protamine on Contraction of Tracheal Smooth Muscle Induced by Carbachol in the Guinea Pig
- Effect of diazepam on the oxytocin induced contraction of the isolated rat uterus
- The Inhibitory Effects of Midazolam and Diazepam on Smooth Muscle Tension in Rat Trachea
- Inhibitory Effects of Potassium Channel Blockers on Carbachol-induced Contraction in Rat Detrusor Muscle
- The Pharmacological and Histological Comparison Between Detubularized and Tubularized Cystoplasty Ileum in the Rat
