Korean J Obstet Gynecol.  2008 Nov;51(11):1239-1244.

The association between adverse pregnancy outcomes and the serum inhibin A levels in mid-trimester of gestation

• Oh HM
• Kim SY
• Lee SP
• Sohn YK
• Lee GH
• Kim JM

Abstract

OBJECTIVES
To investigate the association between abnormal inhibin-A level in Quad test during the 15 and 18 weeks of gestation and adverse pregnancy outcomes.
METHODS
From January 2005 to March 2007, women who delivered their babies at our institute after Quad test in second trimester of gestation (N=140) were enrolled. We measured inhibin-A levels (MoM) and other serum markers of the Quad test. And we analyzed the incidence of adverse pregnancy outcomes such as preterm birth, fetal growth restriction, pregnancy induced hypertension, fetal loss, and intrauterine fetal death.
RESULTS
When the pregnancy outcomes are hypertensive disorders and fetal losses, the inhibin-A levels are is more elevated with statistically significance. Inhibin-A and hCG levels are elevated with significantly at hypertensive disorders and fetal losses. But inhibin-A levels are more significantly associated with abnormal pregnancy outcomes than hCG.
CONCLUSIONS
Measurement of inhibin-A levels may be the most useful among other serum markers of the Quad test in predicting adverse obstetric outcomes.

Keyword

Quad test; Inhibin-A; Preeclampsia; Fetal loss

MeSH Terms

Adenine
Biomarkers
Carbamates
Deoxycytidine
Drug Combinations
Female
Fetal Death
Fetal Development
Humans
Hypertension, Pregnancy-Induced
Incidence
Inhibins
Organophosphonates
Pre-Eclampsia
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, Second
Premature Birth
Quinolones
Thiazoles
Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
Adenine
Carbamates
Deoxycytidine
Drug Combinations
Inhibins
Organophosphonates
Quinolones
Thiazoles