J Korean Med Sci.  2006 Jun;21(3):452-456. 10.3346/jkms.2006.21.3.452.

Maternal Serum and Amniotic Fluid Inhibin A Levels in Women who Subsequently Develop Severe Preeclampsia

• Kim SY
• Ryu HM
• Yang JH
• Kim MY
• Ahn HK
• Shin JS
• Choi JS
• Park SY
• Kim JM
• Lee BY
• Kim DJ

• KMID: 1778427
• DOI: http://doi.org/10.3346/jkms.2006.21.3.452

Abstract

The purpose of this study was to evaluate whether maternal serum (MS) and amniotic fluid (AF) inhibin A levels are elevated in patients who subsequently develop severe preecalmpsia, and to investigate the correlation between MS and AF inhibin A levels in the second trimester. The study included 40 patients who subsequently developed severe preecalmpsia and 80 normal pregnant women. Inhibin A levels in MS and AF were measured with enzyme-linked immunosorbent assay (ELISA). The MS and AF inhibin A levels in patients who developed severe preeclampsia were significantly higher than those in the control group (both for p<0.001). There was a positive correlation between MS and AF inhibin A levels in patients who developed severe preeclampsia (r=0.397, p=0.011), but not in the control group (r=0.185, p=0.126). The best cutoff values of MS and AF inhibin A levels for the prediction of severe preeclampsia were 427 pg/mL and 599 pg/mL, respectively; the estimated ORs that were associated with these cut-off values were 9.95 (95% CI 3.8-25.9, p<0.001) and 6.0 (95% CI 2.3-15.8, p<0.001). An elevated level of inhibin A in MS and AF at the time of second trimester amniocentesis may be a risk factor for the subsequent development of severe preeclampsia.

Keyword

Pre-Eclampsia; inhibin A; Biological Markers; Serum Marker; Maternal Serum; Amniotic Fluid

MeSH Terms

Risk Factors
Pregnancy Trimester, Second
Pregnancy Outcome
Pregnancy
Pre-Eclampsia/*blood/*metabolism
Middle Aged
Maternal Age
Inhibins/*biosynthesis/*blood
Humans
Gestational Age
Female
Case-Control Studies
Amniotic Fluid/*metabolism
Amniocentesis
Adult

Figure

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  Fig. 1 Levels of maternal serum (A) and amniotic fluid inhibin A (B) in normal pregnancy (NP) and patients with severe preeclampsia (SPE). *Statistically significant, p<0.05.

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  Fig. 2 Correlation between maternal serum and amniotic fluind inhibin A levels in the patients with severe preeclampsia.

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