Korean J Perinatol.  2010 Jun;21(2):147-154.

The Differences in Second Trimester Quad Test Markers in Patients with Severe Preeclampsia Depending on the Disease Onset Time and the Presence of Fetal Growth Restriction

• Ahn HS
• Choi IJ
• Lee SY
• Kim MJ
• Kim HJ
• Cha MS
• Kang JY
• Han MS

Abstract

OBJECTIVE
To compare the differences in the second trimester Quad test markers in patients who subsequently developed preeclampsia depending on the disease onset time and the presence of fetal growth restriction (FGR).
METHODS
A retrospective study was carried out on 66 women with severe preeclampsia and 345 controls who were delivered at Dong-A University hospital and Ilsin Christian Hospital from January 2006 to December 2008. Severe preeclampsia patients were grouped according to with (n=30) or without (n=36) FGR. Severe preeclampsia patients were also grouped according to early onset (n=16) or late onset (n=50) The levels of the second trimester human chorionic gonadotropin (hCG), inhibin-A, unconjugated estriol (uE3), alpha-fetoprotein (AFP) were compared in each group.
RESULTS
In the pregnancies that subsequently developed severe preeclampsia, the second trimester hCG, inhibin-A and AFP were significantly higher than the controls. We found that levels of hCG, inhibin-A in severe preeclampsia complicated by FGR were significantly higher than those without FGR. We also found that levels of AFP and inhibin-A in early onset severe preeclampsia were significantly higher than late onset severe preeclampsia.
CONCLUSION
The levels of second trimester Quad test markers in patients that subsequently developed severe preeclampsia were different according to with or without FGR and onset time.

Keyword

Quad test markers; Preeclampsia; Fetal growth restriction; Early onset; Late onset

MeSH Terms

Adenine
alpha-Fetoproteins
Carbamates
Chorionic Gonadotropin
Deoxycytidine
Drug Combinations
Estriol
Female
Fetal Development
Humans
Organophosphonates
Pre-Eclampsia
Pregnancy
Pregnancy Trimester, Second
Quinolones
Retrospective Studies
Thiazoles
Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
Adenine
Carbamates
Chorionic Gonadotropin
Deoxycytidine
Drug Combinations
Estriol
Organophosphonates
Quinolones
Thiazoles
alpha-Fetoproteins